Continually Updated Clinical Reference
 
 
  All Sources     eMedicine     Medscape     Drug Reference     MEDLINE
 
eMedicine - Meniscus Injuries : Article by

Quick Find
Authors & Editors
Introduction
Clinical
Differentials
Workup
Treatment
Medication
Follow-up
Miscellaneous
References

Related Articles
Anterior Cruciate Ligament Injury

Contusions

Iliotibial Band Syndrome

Knee Osteochondritis Dissecans

Lateral Collateral Knee Ligament Injury

Lumbosacral Radiculopathy

Medial Collateral Knee Ligament Injury

Medial Synovial Plica Irritation

Patellofemoral Joint Syndromes

Pes Anserine Bursitis

Posterior Cruciate Ligament Injury




Patient Education
Foot, Ankle, Knee, and Hip Center

Arthritis Center

Knee Injury Overview

Knee Injury Causes

Knee Injury Symptoms

Knee Injury Treatment

Knee Pain Introduction




Author: Bradley S Baker, MD, Clinical Professor, Department of Orthopedic Surgery and Orthopedic Sports Medicine, Sanford School of Medicine, University of South Dakota; Orthopedic Consultant/Team Physician, Sanford Sports Medicine

Bradley S Baker is a member of the following medical societies: American Academy of Orthopaedic Surgeons, American College of Sports Medicine, American Orthopaedic Society for Sports Medicine, Arthroscopy Association of North America, and Mid-America Orthopaedic Association

Coauthor(s): James Lubowitz, MD, Director, Taos Orthopedic Institute, Holy Cross Hospital of Taos; Clinical Professor, Department of Orthopedic Surgery, University of New Mexico

Editors: Leslie Milne, MD, Assistant Clinical Instructor, Department of Emergency Medicine, Harvard University School of Medicine; Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine; Henry T Goitz, MD, Chief, Sports Medicine, Associate Professor, Department of Orthopaedic Surgery, Medical College of Ohio; Jon B Whitehurst, MD, Clinical Instructor of Surgery, University of Illinois College of Medicine; Partner and Executive Board Member, Rockford Orthopedic Associates; Orthopedic Chairman, Rockford Memorial Hospital; Craig C Young, MD, Professor, Departments of Orthopedic Surgery and Community and Family Medicine, Medical Director of Sports Medicine, Sports Medicine Fellowship Director, Medical College of Wisconsin

Author and Editor Disclosure

Synonyms and related keywords: acute meniscal tears, meniscal tear, medial meniscus, lateral meniscus, meniscus tear, meniscal injury, knee injury, meniscectomy, discoid meniscus, McMurray test, Steinmann test, Apley test, Bragard sign, Böhler sign, Payr sign, Merke sign, Childress sign, Finochietto sign

Background

Our understanding of the meniscus has changed radically in the last century. In 1887, Sutton described the meniscus as "the functionless remains of a leg muscle."1 Not until 1948 did Fairbanks appreciate that "meniscectomy is not wholly innocuous," in his classic report of postmeniscectomy radiographic changes.2 Research and knowledge of the meniscus has continued. The critical importance of the meniscus of the knee joint is now understood.

For excellent patient education resources, visit eMedicine's Foot, Ankle, Knee, and Hip Center and Arthritis Center. Also, see eMedicine's patient education articles Knee Pain and Knee Injury.

Related eMedicine topics:
Discoid Meniscus
Knee Injury, Soft Tissue
Knee, Meniscal Tears (MRI)

Related Medscape topics:
Resource Center Exercise and Sports Medicine
Resource Center Joint Disorders
Resource Center Trauma
Specialty Site Orthopaedics
CME Diagnosing and Treating Leg Pain in the Primary Care Setting: Raising Awareness of Prevalence and Pathophysiology (Slides With Transcript)
CME Overweight, Obesity Linked to Knee Replacement for Osteoarthritis
Golf Puts High Stress on Replacement Knees

Frequency

United States

  • Meniscal injuries may be the most common knee injury. The prevalence of acute meniscal tears is 61 cases per 100,000 persons.
  • The overall male-to-female incidence is approximately 2.5:1. The peak incidence of meniscal injury for males is in those aged 31-40 years. For females, the peak incidence is in those aged 11-20 years.
  • In patients older than 65 years, the rate of degenerative meniscal tears is 60%. Surgical procedures of the meniscus are performed on an estimated 850,000 patients each year.3

International

Estimates indicate that at least twice the number of meniscus procedures in the United States are performed worldwide.

Functional Anatomy

The menisci are 2 semilunar wedges in the knee joint positioned between the tibia and the femur. They are essentially extensions of the tibia that act to deepen the articular surfaces of the otherwise relatively flat tibial plateau to accommodate the relatively round femoral condyles. The superior surfaces are concave and in contact with the femoral condyles; the inferior surfaces are flat and conform to the tibial plateaus. The peripheral, convex borders of the menisci are thick and attach to the joint capsule; the opposite border tapers inward to a thin, free edge centrally. Therefore, menisci have a triangular shape in cross section. Each covers approximately two thirds of the corresponding articular surface of the tibia. The medial and lateral menisci each have distinct, individual anatomic characteristics.4, 5, 6

The medial meniscus is semicircular or C-shaped and approximately 3.5 cm in length from anterior to posterior. It is asymmetric with a considerably wider posterior horn than anterior horn. Peripherally, the medial meniscus is continuously attached to the joint capsule, with the middle portion being more firmly attached via connection with fibers of the deep medial collateral ligament. It is anchored to the tibia by the coronary (meniscotibial) ligaments.

The posterior horn of the medial meniscus inserts in the posterior intercondylar fossa directly anterior to the posterior cruciate ligament. The anterior horn attachment is more variable, distributed in a 6- to 8-mm area anterior to the anterior cruciate ligament (ACL) tibial attachment in the anterior intercondylar fossa. Some anterior fibers attach over the anterior periphery of the tibial articular surface, and some posterior fibers of the anterior horn merge with the transverse meniscal ligament that connects to the lateral meniscus.

The lateral meniscus is more nearly circular or O-shaped and covers a larger portion of the tibial plateau surface than the medial meniscus. Its length from anterior to posterior is slightly less than the medial meniscus, and it has an almost uniform width. There is attachment to the joint capsule peripherally, except in the region of the middle one third, where there is no attachment but rather a hiatus for the popliteal tendon.

Unlike the medial meniscus, there is no attachment of the lateral meniscus to the lateral collateral ligament, but the lateral meniscus is anchored to the tibia via coronary (meniscotibial) ligaments. Posteriorly, the lateral meniscus is uniquely attached to the medial femoral condyle by meniscofemoral ligaments. These ligaments are highly variable and pass anterior (ligament of Humphrey) and/or posterior (ligament of Wrisberg) to the posterior cruciate ligament. The posterior attachment to the tibia is just anterior to the medial meniscus attachment in the posterior intercondylar fossa. The anterior horn inserts anterior to the lateral tibial spine and in close proximity to the ACL tibial insertion. Some fibers actually may blend into the ACL.

Despite their attachments, both menisci have mobility. The medial meniscus, with excursion of approximately 5 mm, is half as mobile as the lateral meniscus, whose mobility may exceed 10 mm. The anterior horns are more mobile than the posterior horns. This mobility allows for improved conformity of the tibiofemoral joint. Because the posterior horn of the medial meniscus has the least movement, it is at greatest risk for disruption.

The microanatomy of the meniscus is dense fibrocartilage composed of cells and an extracellular matrix of collagen fibers in network. The cells are termed fibrochondrocytes because they appear to be a mixture of fibroblasts and chondrocytes. These cells are responsible for the synthesis and maintenance of the extracellular fibrocartilaginous matrix.

The most abundant component of the menisci is collagen (75%)—mainly type I collagen (>90%) but it also contains types II, III, V, and VI. Collagen fibers are arranged mostly along a longitudinal or circumferential direction, with some interwoven radial and oblique fibers. The circumferential fibers are related directly to the menisci's functional ability to dissipate compressive loads. The other fibers act primarily as ties to enhance structural rigidity and to help prevent longitudinal splitting. The extracellular matrix also includes proteoglycans, glycoproteins, and elastin.

Most meniscal tissue is avascular and depends on passive diffusion and mechanical pumping to provide nutrition to the fibrocytes within the meniscal substance. Arnoczky and Warren demonstrated the important vascular anatomy of the menisci.7, 8 The limited peripheral blood supply originates from the medial and lateral inferior and superior geniculate arteries. Branches from these vessels give rise to a perimeniscal capillary plexus within the synovium and joint capsule, which, in turn, supplies the meniscus periphery.

Studies have shown that 10-30% of the periphery of the medial meniscus and 10-25% of the lateral meniscus receives a vascular supply; the remainder receives its nutrition from the synovial fluid from passive diffusion and mechanical pumping. A few terminal branches of these vessels, along with the middle geniculate artery through the synovial covering of the anterior and posterior horn attachments, supply increased vascularity to the meniscal horns. The potential for vascular ingrowth is essential for successful meniscal healing and surgical repair. Various zones of the meniscus are described based on the blood supply; the red zone is the well-vascularized periphery, the red-white zone is the middle portion with vascularity peripherally but not centrally, and the white zone is the central avascular portion.

The neuroanatomy of the meniscus is not well described. However, the distribution of neural elements has been demonstrated in essentially the same anatomic distribution as the vascular supply. The anterior and posterior horns are the most richly innervated, and the body innervation follows the pattern along the periphery. Although not entirely clear, these nerve endings are believed to play a role in sensory feedback and proprioception. The greater innervation of the horns of the meniscus reflects the need for feedback at the extremes of flexion and extension, when the meniscal horns are compressed and neural elements are activated.4, 5, 6

The meniscus has unique anatomic properties. An understanding of this anatomy is essential to comprehending its important functions, which include load bearing, load and force distribution, joint stability, joint lubrication, and proprioception.4, 5, 9 One of the primary functions is to provide load bearing across the knee joint. Fifty percent of the compressive load in the knee is transferred by the menisci in extension, whereas up to 85% of the load is transferred at 90° of flexion. The collagen orientation makes this load bearing possible by converting the compressive forces to tensile forces.

Load and forces are distributed across a much larger surface area because of the menisci, which (1) decrease focal contact pressure by increasing the contact area and (2) protect the underlying articular cartilage. Resection of 15-34% of a meniscus may increase contact pressure by more than 350%. Normal knees have 20% better shock-absorbing capacity than meniscectomized knees.

Joint stability is increased because of meniscal structure, which allows increased congruence and conformity between the femoral condyles and tibial plateaus.4, 5 The wedge-shaped meniscus attached to the tibia serves as a secondary stabilizer. For example, the posterior horn acts as a shim to resist anterior tibial translation relative to the femur. Meniscectomy alone may not increase knee laxity, but it has been shown that in association with ACL deficiency, anterior laxity is increased. Meniscal lubrication occurs by fluid exudation across the surface, much like articular cartilage.

The classification of meniscal tears provides a description of pathoanatomy. The types of meniscus tears are (1) longitudinal tears that may take the shape of a bucket handle if displaced, (2) radial tears, (3) parrot-beak or oblique flap tears, (4) horizontal tears, and (5) complex tears that combine variants of the above.

Related Medscape topics:
Resource Center Joint Disorders
Resource Center Vascular Surgery
Specialty Site Orthopaedics



History

Most meniscal injuries can be diagnosed by obtaining a detailed history. Important points to address include the following:

  • Mechanism of injury
    • Meniscus tears are sometimes related to trauma , but significant trauma is not necessary. A sudden twist or repeated squatting can tear the meniscus. The timing of the injury is important to note, although patients often cannot describe a specific event.
    • Meniscus tears typically occur as a result of twisting or change of position of the weight-bearing knee in varying degrees of flexion or extension.
  • Pain
    • Pain from meniscus injuries is commonly intermittent and is usually the result of synovitis or abnormal motion of the unstable meniscus fragment.
    • The pain is usually localized to the joint line.
  • Mechanical complaints: Descriptions by patients are often nonspecific but include reports of clicking, catching, locking, pinching, or a sensation of giving way.
  • Swelling
    • Swelling usually occurs as a delayed symptom or may not occur at all. Immediate swelling indicates a tear in the peripheral vascular aspect.
    • Degenerative tears often manifest with recurrent effusions due to synovitis.

Physical

A complete examination, including that of the lower spine, ipsilateral hip and thigh, patellofemoral joint, and tibiofemoral joint, is essential when evaluating knee pain. Associated findings such as a perimeniscal cyst or ligamentous laxity suggest a higher likelihood of a meniscus injury. Important findings when examining a patient with a possible meniscus injury include the following:

  • Joint line tenderness
    • Joint line tenderness is an accurate clinical sign.10 This finding indicates injury in 77-86% of patients with meniscus tears. Despite the high predictive value, operative findings occasionally differ from the preoperative assessment.
    • The examiner must differentiate collateral ligament tenderness that may extend further toward the ligament attachment sites, above and below the joint line.
  • Effusion
    • Effusion occurs in approximately 50% of the patients presenting with a meniscus tear.
    • The presence of an effusion is suggestive of a peripheral tear in the vascular or red zone (especially when acute), an associated intra-articular injury, or synovitis.
  • Range of motion
    • A mechanical block to motion or frank locking can occur with displaced tears.
    • Restricted motion caused by pain or swelling is also common.
  • Provocative maneuvers: These techniques cause impingement by creating compression and/or shearing forces on the torn meniscus between the femoral and tibial surfaces.
    • The McMurray test
      • This maneuver usually elicits pain or a reproducible click in the presence of a meniscal tear. The medial meniscus is evaluated by extending the fully flexed knee with the foot/tibia internally rotated while a varus stress is applied. The lateral meniscus is evaluated by extending the knee from the fully flexed position, with the foot/tibia externally rotated while a valgus stress is applied to the knee. One of the examiner's hands should be palpating the joint line during the maneuver.
    • The Steinmann test,
      • Tibial rotation is performed with the patient seated and the knee flexed 90º. Asymmetric pain is created with external (medial meniscus) or internal (lateral meniscus) rotation.
    • The Apley test
      • This maneuver is performed with the patient prone and the knee flexed 90º. An axial load is applied through the heel as the lower leg is internally and externally rotated. This grinding maneuver is suggestive of meniscal pathology if pain is elicited at the medial or lateral joint.
    • Similar tests, including those that elicit the Bragard sign, Böhler sign, Payr sign, Merke sign, Childress sign, and Finochietto sign, are based on the provocative principle.



Anterior Cruciate Ligament Injury
Contusions
Iliotibial Band Syndrome
Knee Osteochondritis Dissecans
Lateral Collateral Knee Ligament Injury
Lumbosacral Radiculopathy
Medial Collateral Knee Ligament Injury
Medial Synovial Plica Irritation
Patellofemoral Joint Syndromes
Pes Anserine Bursitis
Posterior Cruciate Ligament Injury

Other Problems to Be Considered

Articular cartilage pathology, including arthritis and neoplastic pathology

Crystalline deposition diseases, including gout and pseudogout (chondrocalcinosis)

Ipsilateral hip disease

Osteonecrosis of the femur or tibia

Plica

Secondary gain issues, including workers' compensation claims or pending litigation



Imaging Studies

  • Plain radiography: An anteroposterior weight-bearing view, posteroanterior 45º flexed view, lateral view, and Merchant patellar view should be obtained to rule out degenerative joint changes (arthritis) or fractures.
  • Arthrography: Historically, arthrography was the standard imaging study for meniscal tears, but it has been replaced by magnetic resonance imaging (MRI).
  • MRI: This is the criterion standard imaging study for imaging meniscus pathology and all intra-articular disorders.11, 12
    • Normal menisci have a homogeneous low signal. Abnormal meniscal signals are classified into the following 3 groups:
      • Grade I Small area of increased signal within the meniscus
      • Grade II Linear area of increased signal that does not extend to an articulating surface
      • Grade III Abnormal increased signal that reaches the surface or edge of the meniscus
    • Grade I and II changes are common in older patients as evidence of the normal aging degenerative process and in young patients as normal perforating vascular channels. Grade I and II changes are not usually seen arthroscopically and do not represent meniscal tears. Grade III changes are meniscal tears.
    • MRI has proven to be an effective technique for evaluating menisci.
      • Average sensitivity 95% medial, 81% lateral
      • Average specificity 88% medial, 96% lateral
      • Average accuracy 92% medial, 92% lateral

Procedures

  • Arthroscopy
    • In the hands of a competent arthroscopist, arthroscopy is considered the best tool for meniscal tear diagnosis, with sensitivity, specificity, and accuracy approaching 100%.
    • Arthroscopy is therapeutic and diagnostic and thus offers the advantage of immediate treatment of most disorders.12, 13, 14



Acute Phase

Rehabilitation Program

Physical Therapy

A home physical therapy program or simple rest with activity modification, ice, and nonsteroidal anti-inflammatory drugs (NSAIDs) is the nonoperative management of possible meniscus tears. The physical therapy program goals are to minimize the effusion, normalize gait, normalize pain-free range of motion, prevent muscular atrophy, maintain proprioception, and maintain cardiovascular fitness. Choosing this course of treatment must include consideration of the patient's age, activity level, duration of symptoms, type of meniscus tear, and associated injuries such as ligamentous pathology. A trial of conservative treatment should be attempted in all but the most severe cases, such as a locked knee secondary to a displaced bucket-handle tear.

Medical Issues/Complications

The main complication at this stage of treatment is the absence of healing and failure of symptoms to resolve. The natural history of a short (<1 cm), vascular, longitudinal tear is often one of healing or resolution of symptoms. Stable tears with minimal displacement, degenerative tears, or partial-thickness tears may become asymptomatic with nonoperative management.15
 
Most meniscal tears do not heal without intervention. If conservative treatment does not allow the patient to resume desired activities, his or her occupation, or a sport, surgical treatment is considered. Surgical treatment of symptomatic meniscal tears is recommended because untreated tears may increase in size and may abrade articular cartilage, resulting in arthritis (see Treatment, Acute Phase, Surgical Intervention).

Related Medscape topics:
Resource Center Exercise and Sports Medicine
Resource Center Joint Disorders
Specialty Site Orthopaedics

Surgical Intervention

If symptoms persist, if the patient cannot risk the delay of a potentially unsuccessful period of observation (eg, elite athletes), or in cases of a locked knee, surgical treatment is indicated.

The basic principle of meniscus surgery is to save the meniscus. Tears with a high probability of healing with surgical intervention are repaired. However, most tears are not repairable and resection must be restricted to only the dysfunctional portions, preserving as much normal meniscus as possible.

Surgical options include partial meniscectomy or meniscus repair (and in cases of previous total or subtotal meniscectomy, meniscus transplantation). Arthroscopy, a minimally invasive outpatient procedure with lower morbidity, improved visualization, faster rehabilitation, and better outcomes than open meniscal surgery, is now the standard of care.

Partial meniscectomy is the treatment of choice for tears in the avascular portion of the meniscus or complex tears that are not amenable to repair. Torn tissue is removed, and the remaining healthy meniscal tissue is contoured to a stable, balanced peripheral rim.

Meniscus repair is recommended for tears that occur in the vascular region (red zone or red-white zone), are longer than 1 cm, involve greater than 50% of the meniscal thickness, and are unstable to arthroscopic probing. A stable knee is important for successful meniscus repair and healing. Thus, associated ligamentous injuries must be addressed. The most commonly associated ligamentous disruption is complete tear of the ACL, which must be reconstructed to prevent recurrent meniscal tears. Fortunately, the increased blood and growth factors in the knee during meniscal repair combined with cruciate reconstruction significantly improves the outcome of the meniscal repair. In ACL-intact knees with isolated meniscal tears, healing rates are less than those in ACL-reconstructed knees, but they are higher than those in ACL-deficient knees.

The principles of repair include smoothing and abrading the torn edges and bordering synovium to promote bleeding and healing. Likewise, needle trephination of the meniscal body (poking holes to create vascular channels) can be performed.

Meniscus repair fixation techniques are numerous and variable. Fixation can be accomplished with outside-in, inside-out, or all-inside arthroscopic procedures.4, 16, 17, 18 The outside-in and inside-out methods are usually performed with sutures and require additional incisions. Suture repair can be accomplished with vertical or horizontal stitches. The all-inside method is very popular, and a plethora of commercially available meniscus repair devices are available (eg, biodegradable arrows or darts). Note: A word of caution may be appropriate. Peer-reviewed clinical studies regarding the efficacy of these new devices are lacking. The criterion standard to which these devices must be compared remains the inside-out vertical mattress suture.

Human allograft meniscal transplantation is a relatively new procedure but is being performed increasingly frequently. Specific indications and long-term results have not yet been clearly established. Meniscus transplantation requires further investigation to assess its efficacy in restoring normal meniscus function and preventing arthrosis.

Related eMedicine topics:
Anterior Cruciate Ligament Injury
Knee, Anterior Cruciate Ligament Injuries (MRI)

Related Medscape topics:
Resource Center Surgery
Resource Center Surgical Blood Management

Recovery Phase

Rehabilitation Program

Physical Therapy

Physical therapy during recovery is directed toward the same goals as those in the acute phase. For partial meniscectomy, patients may return to low-impact or nonimpact workouts such as stationary cycling or straight-leg raising on the first postoperative day and may advance rapidly to preoperative activities. In most patients, this can usually be accomplished without formal physical therapy. However, evidence suggests that the quadriceps remains weaker than that of the contralateral side for up to 12 weeks; therefore, therapy should be initiated if deficits persist.

When a meniscus repair is performed, the rehabilitation is typically more intensive. Many different protocols are described in the literature. Three main issues are considered in the rehabilitation of meniscus repairs: knee motion, weight bearing, and return to sports.18 A common protocol is avoidance of weight bearing for 4-6 weeks, with full motion encouraged. A more aggressive approach is promoted by some surgeons. The authors' protocol is to allow full weight bearing with the knee braced and locked in full extension for 6 weeks, while encouraging full motion when the knee is not bearing weight. Note that meniscal rehabilitation must not interfere with concomitant ACL rehabilitation.

Medical Issues/Complications

Reported complication rates for arthroscopic meniscectomy range from 0.5-1.7%, and these can occur intraoperatively or postoperatively. Intraoperative complications include anesthetic problems, articular cartilage damage, vessel or nerve injury, or instrument failure. Postoperative complications include anesthetic concerns, thrombophlebitis, hemarthrosis, infection, stiffness, persistent pain, effusion, or synovitis.

Reported complication rates for meniscus repairs range from 1-30%. The list of complications is the same as that for meniscectomies, with a greater concern for neurovascular injury. Additionally, failure to heal or meniscal reinjury can occur.

Related Medscape topics:
Resource Center Pain Management: Pharmacologic Approaches
Resource Center Patient Safety
Resource Center Wound Management



Medical therapy is used in the treatment of meniscal injuries. It can be used during trials of nonoperative management with associated rest, ice, and a rehabilitation program. If surgical treatment is indicated, medical therapy is valuable in postoperative management.

Drug Category: Nonsteroidal anti-inflammatory drugs

NSAIDs are a first-line medical therapy. The goal with the use of these agents is to reduce pain and inflammation during early attempts at conservative management of meniscal tears or during the postoperative period following surgical treatment. Myriad drugs are available. A few are listed below, including the newer cyclooxygenase (COX)-2 inhibitors. The COX-2 inhibitors are more specifically directed at inflammation and pain without the gastrointestinal (GI) toxicity.

Related eMedicine topic:
Toxicity, Nonsteroidal Anti-inflammatory Agents

Related Medscape topic:
Resource Center Adverse Drug Events Reporting

Drug NameIbuprofen (Motrin, Ibuprin)
DescriptionDOC for mild to moderate pain. Inhibits inflammatory reactions and pain by decreasing prostaglandin synthesis.
Adult Dose200-400 mg PO q4-6h while symptoms persist; not to exceed 3.2 g/d
Pediatric Dose<6 months: Not established

6 months to 12 years: 4-10 mg/kg/dose PO tid/qid

>12 years: Administer as in adults
ContraindicationsDocumented hypersensitivity; peptic ulcer disease; recent GI bleeding or perforation; renal insufficiency; high risk of bleeding
InteractionsCoadministration with aspirin increases the risk of inducing serious NSAID-related adverse effects; probenecid may increase the concentrations and, possibly, the toxicity of NSAIDs; may decrease the effect of hydralazine, captopril, and beta-blockers; may decrease the diuretic effects of furosemide and thiazides; may increase PT duration when taking anticoagulants (instruct patients to watch for signs of bleeding); may increase the risk of methotrexate toxicity; phenytoin levels may be increased when administered concurrently
PregnancyB - Fetal risk not confirmed in studies in humans but has been shown in some studies in animals
D - Fetal risk shown in humans; use only if benefits outweigh risk to fetus
PrecautionsCaution in patients with congestive heart failure, hypertension, and decreased renal and hepatic function; caution in the presence of coagulation abnormalities or during anticoagulant therapy

Drug NameCelecoxib (Celebrex)
DescriptionInhibits primarily COX-2, which is considered an inducible isoenzyme; induced during pain and inflammatory stimuli. Inhibition of COX-1 may contribute to NSAID GI toxicity. At therapeutic concentrations, COX-1 isoenzyme is not inhibited; thus, GI toxicity may be decreased. Seek lowest dose for each patient.
Adult Dose200 mg/d PO qd; alternatively, 100 mg PO bid
Pediatric DoseNot established
ContraindicationsDocumented hypersensitivity
InteractionsCoadministration with fluconazole may cause an increase in celecoxib plasma concentrations because of inhibition of celecoxib metabolism; coadministration with rifampin may decrease celecoxib plasma concentrations.
PregnancyB - Fetal risk not confirmed in studies in humans but has been shown in some studies in animals
PrecautionsMay cause fluid retention and peripheral edema; caution in patients with compromised cardiac function, hypertension, and conditions predisposing to fluid retention; caution in the presence of severe heart failure and hyponatremia because circulatory hemodynamics may deteriorate; NSAIDs may mask the usual signs of infection; caution in the presence of existing controlled infections; evaluate symptoms and signs that suggest liver dysfunction or with abnormal liver laboratory results

Drug Category: Analgesics

Analgesics are an alternative therapy to NSAIDs with similar indications. These agents are directed primarily at controlling pain and do not have an anti-inflammatory effect.

Related Medscape topics:
Resource Center Pain Management: Advanced Approaches to Chronic Pain Management
Resource Center Pain Management: Pharmacologic Approaches

Drug NameAcetaminophen (Tylenol, Feverall, Aspirin-Free Anacin)
DescriptionDOC for pain in patients with documented hypersensitivity to aspirin or NSAIDs, with upper GI disease, or who are taking oral anticoagulants.
Adult Dose325-650 mg PO q4-6h or 1000 mg tid/qid; not to exceed 4 g/d
Pediatric Dose<12 years: 10-15 mg/kg/dose PO q4-6h prn; not to exceed 2.6 g/d

>12 years: 325-650 mg PO q4h; not to exceed 5 doses in 24 h
ContraindicationsDocumented hypersensitivity; known G6PD deficiency
InteractionsRifampin can reduce analgesic effects; coadministration with barbiturates, carbamazepine, hydantoins, and isoniazid may increase hepatotoxicity.
PregnancyB - Fetal risk not confirmed in studies in humans but has been shown in some studies in animals
PrecautionsHepatotoxicity is possible in persons with chronic alcoholism following various dose levels; severe or recurrent pain or high or continued fever may indicate a serious illness; acetaminophen is contained in many OTC products, and combined use with these products may result in cumulative acetaminophen doses that exceed the recommended maximum dose.

Drug Category: Narcotic analgesics

Narcotic analgesics should be used sparingly in the conservative treatment period. The use of these agents is warranted only in special cases in which intolerable pain is present that cannot be controlled by the first-line drugs. However, these drugs are commonly used in the postoperative period when surgical treatment is necessary. Many options are available, and narcotic analgesics are commonly combined with drugs from the above categories. Common examples are listed.

Related eMedicine topic:
Toxicity, Narcotics

Drug NameHydrocodone and acetaminophen (Vicodin, Lortab, Norcet)
DescriptionDrug combination for moderate to severe pain.
Adult Dose1-2 tab or cap PO q4-6h prn
Pediatric Dose<12 years: 10-15 mg/kg/dose acetaminophen PO q4-6h prn; not to exceed 2.6 g/d acetaminophen

>12 years: 750 mg acetaminophen PO q4h; not to exceed 10 mg hydrocodone bitartrate per dose or 5 doses/24 h
ContraindicationsDocumented hypersensitivity; HACE or elevated ICP
InteractionsCoadministration with phenothiazines may decrease the analgesic effects; toxicity increases with CNS depressants or TCAs
PregnancyC - Fetal risk revealed in studies in animals but not established or not studied in humans; may use if benefits outweigh risk to fetus
PrecautionsThe tablets contain metabisulfite, which may cause hypersensitivity; caution in patients who are dependent on opiates because this substitution may result in acute opiate-withdrawal symptoms; caution in the presence of severe renal or hepatic dysfunction.

The combination formulation includes acetaminophen; therefore, additional doses of independent acetaminophen should be avoided to prevent toxicity.

Drug NameOxycodone (Roxicodone, OxyContin, OxyIR)
DescriptionIndicated for moderate to severe pain.
Adult Dose5 mg PO q6h prn
Pediatric Dose<6 years: Not established

6-12 years: 1.25 mg q6h prn

>12 years: 2.5 mg q6h prn
ContraindicationsDocumented hypersensitivity
InteractionsPhenothiazines may antagonize the analgesic effects; MAOIs, general anesthesia, CNS depressants, and TCAs may increase toxicity.
PregnancyB - Fetal risk not confirmed in studies in humans but has been shown in some studies in animals
D - Fetal risk shown in humans; use only if benefits outweigh risk to fetus
PrecautionsCaution in the presence of COPD, emphysema, or renal insufficiency



Return to Play

Return to play after a meniscus injury is expected. The timing varies and depends on the injury, treatment, and rehabilitation protocol. In many cases, athletes can return to their sport as soon as 2-3 weeks status post arthroscopic partial meniscectomy or 6-8 weeks status post meniscal repair.

Complications

Complications are discussed under Recovery Phase, Medical Issues/Complications. In the long term, meniscal repairs fail to heal in 5-10% of patients. Failure rates are lower when the tears are repaired in patients with concomitant ACL reconstruction.

In patients with untreated tears, enlargement of the tear and arthrosis are common. In patients who are status post partial meniscectomy, arthrosis is also a concern. However, arthroscopists are hopeful that long-term outcome studies will demonstrate that a partial meniscectomy can delay or prevent the degenerative changes noted by Fairbanks in patients who had open total meniscectomy.2

Prevention

Prevention of recurrent problems is accomplished best by reestablishing and maintaining knee fitness with strength, flexibility, and proprioception.

Related Medscape topic:
Resource Center Exercise and Sports Medicine



Medical/Legal Pitfalls

  • Patient expectations: Patients must understand the pathology of their own knees so they have appropriate expectations regarding outcome. Outcomes of treatment and prognosis are individualized depending on the type of injury and the associated joint pathology, such as articular cartilage damage and instability. Appropriate expectations are key to achieving subjectively successful outcomes.

Related Medscape topics:
Resource Center Joint Disorders
Resource Center Medical Malpractice and Legal Issues
Specialty Site Orthopaedics

Special Concerns

  • Discoid meniscus
    • Approximately 5% of the white persons have a disc-shaped lateral meniscus.
    • Discoid meniscus often manifests as snapping of the knee in a patient younger than 10 years.19
    • Radiographic signs include a widened joint space, squaring of the lateral femoral condyle, cupping of the tibial plateau, and hypoplasia of the tibial spine. MRI is the imaging technique of choice.
    • Three types of discoid meniscus have been described.
      • Type I Complete, covers the entire plateau
      • Type II Incomplete
      • Type III (Wrisberg ligament type) Deficiency of the posterior meniscotibial ligaments, resulting in instability of the posterior horn
    • No treatment is required for the asymptomatic discoid meniscus.
    • Symptomatic type I and II discoid menisci warrant arthroscopic partial meniscectomy with saucerization to a normal meniscus shape. Likewise, a torn discoid meniscus requires partial meniscectomy; saucerization, with removal of the tear, often allows preservation of a meniscus of normal morphology. A symptomatic type III discoid meniscus requires stabilization of the posterior horn.



  1. Bland-Sutton J. Ligaments: Their Nature and Morphology. 2nd ed. London, UK: HK Lewis; 1887.
  2. Fairbanks TJ. Knee joint changes after meniscectomy. J Bone Joint Surg Br. 1948;30:664-70. [Full Text].
  3. Arendt EA, ed. Orthopaedic Knowledge Update: Sports Medicine 2. Rosemont, Ill: American Academy of Orthopaedic Surgeons; 1999.
  4. Insall JN, Scott WN, eds. Surgery of the Knee. 3rd ed. Philadelphia, Pa: WB Saunders Co; 2001.
  5. Rodkey WG. Basic biology of the meniscus and response to injury. Instr Course Lect. 2000;49:189-93. [Medline].
  6. Fu FH, Harner CD, Vince KG, eds. Knee Surgery. Philadelphia, Pa: Lippincott Williams & Wilkins; 1994.
  7. Arnoczky SP, Warren RF. The microvasculature of the meniscus and its response to injury. An experimental study in the dog. Am J Sports Med. May-Jun 1983;11(3):131-41. [Medline].
  8. Arnoczky SP, Warren RF. Microvasculature of the human meniscus. Am J Sports Med. Mar-Apr 1982;10(2):90-5. [Medline].
  9. Vaziri A, Nayeb-Hashemi H, Singh A, Tafti BA. Influence of meniscectomy and meniscus replacement on the stress distribution in human knee joint. Ann Biomed Eng. May 22 2008;epub ahead of print. [Medline].
  10. Eren OT. The accuracy of joint line tenderness by physical examination in the diagnosis of meniscal tears. Arthroscopy. Oct 2003;19(8):850-4. [Medline].
  11. Behairy NH, Dorgham MA, Khaled SA. Accuracy of routine magnetic resonance imaging in meniscal and ligamentous injuries of the knee: comparison with arthroscopy. Int Orthop. May 28 2008;epub ahead of print. [Medline].
  12. Nikolaou VS, Chronopoulos E, Savvidou C, et al. MRI efficacy in diagnosing internal lesions of the knee: a retrospective analysis. J Trauma Manag Outcomes. Jun 2 2008;2(1):4. [Medline].
  13. Spindler KP, McCarty EC, Warren TA, Devin C, Connor JT. Prospective comparison of arthroscopic medial meniscal repair technique: inside-out suture versus entirely arthroscopic arrows. Am J Sports Med. Nov-Dec 2003;31(6):929-34. [Medline].
  14. Bin SI, Kim JM, Shin SJ. Radial tears of the posterior horn of the medial meniscus. Arthroscopy. Apr 2004;20(4):373-8. [Medline].
  15. Shelbourne KD, Heinrich J. The long-term evaluation of lateral meniscus tears left in situ at the time of anterior cruciate ligament reconstruction. Arthroscopy. Apr 2004;20(4):346-51. [Medline].
  16. Adachi N, Ochi M, Uchio Y, Kuriwaka M, Shinomiya R. Torn discoid lateral meniscus treated using partial central meniscectomy and suture of the peripheral tear. Arthroscopy. May 2004;20(5):536-42. [Medline].
  17. Kelly JD 4th, Ebrahimpour P. Chondral injury and synovitis after arthroscopic meniscal repair using an outside-in mulberry knot suture technique. Arthroscopy. May 2004;20(5):e49-52. [Medline].
  18. Barber FA, Harding NR. Meniscal repair rehabilitation. Instr Course Lect. 2000;49:207-10. [Medline].
  19. Hart ES, Kalra KP, Grottkau BE, Albright M, Shannon EG. Discoid lateral meniscus in children. Orthop Nurs. May/June 2008;27(3):174-9. [Medline].
  20. Freedman KB, Nho SJ, Cole BJ. Marrow stimulating technique to augment meniscus repair. Arthroscopy. Sep 2003;19(7):794-8. [Medline].
  21. Jerosch J, Riemer S. [How good are clinical investigative procedures for diagnosing meniscus lesions?] [German]. Sportverletz Sportschaden. Jun 2004;18(2):59-67. [Medline].
  22. Metcalf MH, Barrett GR. Prospective evaluation of 1485 meniscal tear patterns in patients with stable knees. Am J Sports Med. Apr-May 2004;32(3):675-80. [Medline].
  23. Pearse EO, Craig DM. Partial meniscectomy in the presence of severe osteoarthritis does not hasten the symptomatic progression of osteoarthritis. Arthroscopy. Nov 2003;19(9):963-8. [Medline].
  24. Uysal M, Akpinar S, Bolat F, et al. Apoptosis in the traumatic and degenerative tears of human meniscus. Knee Surg Sports Traumatol Arthrosc. Apr 30 2008;epub ahead of print. [Medline].

Meniscus Injuries excerpt

Article Last Updated: Jun 5, 2008