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Author: Robert F LaPrade, MD, PhD, Professor, Department of Orthopaedic Surgery, Divisions of Sports Medicine and Shoulder Services, University of Minnesota

Robert F LaPrade is a member of the following medical societies: American Academy of Orthopaedic Surgeons, American Orthopaedic Society for Sports Medicine, and Arthroscopy Association of North America

Coauthor(s): Scott D Flinn, MD, Medical Director, Directorate for Primary Care, Primary Care, Naval Medical Center San Diego

Editors: Gerard A Malanga, MD, Associate Professor, Department of Physical Medicine and Rehabilitation, New Jersey Medical School; Director of Pain Management, University of Medicine and Dentistry at New Jersey, Overlook Hospital; Director of Sports Medicine, Mountainside Hospital; Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine; Russell D White, MD, Professor of Medicine, Department of Community and Family Medicine, University of Missouri-Kansas City School of Medicine, Truman Medical Center Lakewood; Jon B Whitehurst, MD, Clinical Instructor of Surgery, University of Illinois College of Medicine; Partner and Executive Board Member, Rockford Orthopedic Associates; Orthopedic Chairman, Rockford Memorial Hospital; Sherwin SW Ho, MD, Associate Professor, Department of Surgery, Section of Orthopedic Surgery and Rehabilitation Medicine, University of Chicago

Author and Editor Disclosure

Synonyms and related keywords: pes anserine tendonitis/tendinitis, knee bursitis, pes anserinus tendinobursitis/tendino-bursitis syndrome, PATB syndrome

Background

Bursae are small, synovial tissue-lined structures that help different tissues glide over one another, such as a tendon sliding over another tendon or bone. Bursae may become painful when irritated, damaged, or infected.

Pes anserine bursitis is a common finding in patients and/or athletes who present with complaints of anterior knee pain. The pes anserine bursa, along with its associated medial hamstring tendons, is located along the proximomedial aspect of the tibia. This condition is usually found in patients who have tight hamstrings, although it also can be caused by trauma (eg, a direct blow). In most patients, pes anserine bursitis is a self-limiting condition that responds to a program of hamstring stretching and quadriceps strengthening.

Frequency

United States

The exact incidence of pes anserine bursitis is unknown. It is not commonly recorded as an individual entity by many physicians but may be reported with the clinical diagnosis of anterior knee pain or patellofemoral syndrome. Pes anserine bursitis is recognized as occurring in a large number of patients who present to a physician's office with anterior knee pain.

Functional Anatomy

The pes anserine bursa is formed just proximal and medial to the primary attachment of the medial hamstring tendons on the proximal tibia.1 From proximal to distal, the medial hamstring tendons that form the roof of the pes anserine bursa are the sartorius, gracilis, and semitendinosus. The pes anserine bursa serves as a potential space where motion occurs between these hamstring tendons and the underlying superficial medial collateral ligament (tibial collateral ligament).

Sport-Specific Biomechanics

The pes anserine bursa serves as a space where motion occurs between the medial hamstrings and the superficial medial (tibial) collateral ligament. When a patient has tight hamstrings or experiences a contusion to this area, the synovial cells in the lining of the bursa may secrete more fluid and the bursa becomes inflamed and painful.



History

The chief complaint of patients with pes anserine bursitis, either as a main component or as part of several causes of knee pain, is pain along the medial aspect of the knee. Although patients sometimes point to an area directly over the pes anserine bursa, they may often point to a rather diffuse region over the medial aspect of the knee. This diffuse pain may occur because many of these patients may also have plical irritation or medial joint compartment pathology (eg, medial meniscal tears, medial compartment arthritis).

(See also the eMedicine articles Medial Synovial Plica Irritation, as well as Knee, Meniscal Tears (MRI) [in the Radiology section], Pes Anserinus Bursitis [in the Physical Medicine and Rehabilitation section], and Medial Compartment Arthritis [in the Orthopedic Surgery section].)

Physical

On physical examination, the pes anserine bursa can be palpated at a point slightly distal to the tibial tubercle and about 3-4 cm medial to it (about 2 fingerbreadths). Pain in this area indicates an underlying inflammation of the pes anserine bursa or a bursitis. Palpation of this area of the knee is important in a patient who complains of medial-sided knee pain because the examiner needs to ensure that the pain is truly from joint line pathology or from pes anserine bursal pathology (or both).

Concurrent with the physical examination finding, the hamstring-popliteal angle should be assessed to determine the patient's underlying amount of hamstring tightness. This assessment is made by having the patient's hip flex to 90°, and then passively extending the leg. The angle formed between a perpendicular line to the femoral shaft and the tibial shaft is the hamstring-popliteal angle.

At its worst, pes anserine bursal pain is only mild to moderate. Intense pain could suggest a proximal tibial stress fracture.

Causes

The main cause of pes anserine bursitis is underlying tight hamstrings, which are believed to place extra pressure on the bursa, causing bursal irritation. In addition, some patients may have bursal irritation due to a direct blow and experience a contusion to this area, as well as resultant inflammation. Pes anserine bursitis is a common finding in patients who have concurrent Osgood-Schlatter syndrome, suprapatellar plical irritation, or other causes of joint irritation, which may make the hamstrings spasm (eg, meniscal tears, underlying arthritis). Patients with planovalgus feet and the resultant overpronation with running may also be at risk for irritation of the bursa.

(See also the eMedicine articles Osgood-Schlatter Disease and Medial Synovial Plica Irritation [in the Sports Medicine section], as well as Osgood-Schlatter Disease and Acquired Flatfoot [in the Orthopedic Surgery section].)



Jumper's Knee
Knee Osteochondritis Dissecans
Medial Synovial Plica Irritation
Osgood-Schlatter Disease
Patellofemoral Joint Syndromes

Other Problems to Be Considered

Medial meniscal tear
Plica syndrome
Proximal tibia stress/fracture



Lab Studies

  • Infections of the pes anserine bursa are very rare and occur primarily in immunocompromised patients. These patients have a localized area of warmth, pain, and swelling; a standard laboratory workup for infection is indicated, such as an erythrocyte sedimentation rate (ESR) measurement, complete blood cell count with differential ("CBC with diff"), and C-reactive protein (CRP) level.

Imaging Studies

  • Plain radiographs (standing anteroposterior [AP] and lateral views) are useful to rule out a proximal tibial stress fracture, as well as to help diagnose concurrent pathology, such as medial compartment arthritis or osteochondritis dissecans, which could contribute to tight hamstrings and pes anserine bursal irritation.

    (See also the eMedicine articles Knee Osteochondritis Dissecans, as well as Medial Compartment Arthritis and Osteochondritis Dissecans [in the Orthopedic Surgery section].)

  • A magnetic resonance imaging (MRI) study may be useful to help diagnose concurrent pathology of the medial compartment.2 The appearance of pes anserine bursitis on MRI is characterized by increased signal intensity and fluid formation around the area of the pes anserine bursa. MRI is also helpful to rule out a proximal tibial stress fracture.3

Procedures

  • A diagnostic or therapeutic lidocaine or lidocaine/corticosteroid injection into the area of the pes anserine bursa may help the clinician to determine the contribution of this pathology to a patient's overall knee pathology, as well as to possibly cut down on the patient's symptoms.



Acute Phase

Rehabilitation Program

Physical Therapy

Patients with pes anserine bursitis need to work on both a hamstring stretching program and a concurrent closed-chain quadriceps strengthening program. This type of program can usually be taught to the patient by an athletic trainer or physical therapist. Patients should understand that, to gain the maximum benefit from this program, they need to stretch their hamstrings frequently during the day, sometimes hourly. The quadriceps strengthening program is recommended in most patients because of other concurrent pathology in the knee.

A regular program of hamstring stretching and quadriceps strengthening usually results in alleviation of the pain from pes anserine bursitis in approximately 6-8 weeks. Addition of a nonsteroidal anti-inflammatory drug (NSAID) may help to alleviate some of the pain at this time, and an ice massage may help to reduce inflammation. Cutting back or eliminating the offending activities is also important.

Recreational Therapy

In patients with generalized anterior knee pain, activity modification may be necessary to allow the joint to quiet down and to allow the hamstring tightness to resolve. In most patients, this modification involves minimizing the use of stairs, climbing, or other activities that cause irritation of the joint.

Surgical Intervention

The need for surgery is very rare in cases of pes anserine bursitis. Surgery is usually indicated in cases in which an immunocompromised patient has a localized infection that does not resolve with standard antibiotic treatment. Surgical decompression of the bursa may be indicated in such cases.

Consultations

Recalcitrant cases that do not respond to a program of activity modification and exercise may need a referral to a specialty-trained, sports medicine physician, primary care physician, or orthopedic surgeon for evaluation.

Recovery Phase

Rehabilitation Program

Physical Therapy

During the rehabilitation program, the patient should incorporate the following measures:

  • Continue with activity modification as necessary.
  • Begin a gradual resumption of activities.
  • Continue alternative training for cardiovascular fitness.
  • After regaining full, pain-free motion with good isometric strength, work on improving strength and endurance.

Medical Issues/Complications

Pes anserine bursitis is primarily a self-limiting condition, which responds well to an exercise/stretching program.4 Recalcitrant cases should be referred to a specialist to confirm the diagnosis and to rule out other causes of the patient's pain (eg, proximal tibial plateau fracture).

Surgical Intervention

See Treatment, Acute Phase, Surgical Intervention.

Maintenance Phase

Rehabilitation Program

Physical Therapy

Continue to work on a hamstring stretching program and a concurrent closed-chain quadriceps strengthening program.



In general, medications are not frequently used to treat pes anserine bursitis. In cases in which it may be warranted to help alleviate symptoms, the addition of an over-the-counter or prescribed anti-inflammatory medication may be indicated.

Drug Category: Nonsteroidal anti-inflammatory drugs

NSAIDs have analgesic and anti-inflammatory activities. Their mechanism of action is not known, but they may inhibit cyclooxygenase activity and prostaglandin synthesis. Other mechanisms may exist as well, such as inhibition of leukotriene synthesis, lysosomal enzyme release, lipoxygenase activity, neutrophil aggregation, and various cell membrane functions.

Drug NameIbuprofen (Motrin, Ibuprin)
DescriptionDOC for patients with mild to moderate pain. Inhibits inflammatory reactions and pain by decreasing prostaglandin synthesis.
Adult Dose200-800 mg PO tid
Pediatric DoseNot established
ContraindicationsDocumented hypersensitivity; patients with peptic ulcer disease, recent GI bleeding or perforation, renal insufficiency, or high risk of bleeding
InteractionsCoadministration with aspirin increases the risk of inducing serious NSAID-related side effects; probenecid may increase the concentrations and, possibly, toxicity of NSAIDs; may decrease the effect of hydralazine, captopril, and beta-blockers; may decrease the diuretic effects of furosemide and thiazides; monitor PT duration closely (instruct patients to watch for signs of bleeding); may increase the risk of methotrexate toxicity; phenytoin levels may be increased when administered concurrently
PregnancyB - Fetal risk not confirmed in studies in humans but has been shown in some studies in animals
PrecautionsCategory D in third trimester of pregnancy; caution in patients with congestive heart failure, hypertension, and decreased renal and hepatic function; caution in the presence of anticoagulation abnormalities or during anticoagulant therapy

Drug NameKetoprofen (Orudis, Oruvail, Actron)
DescriptionFor relief of mild to moderate pain and inflammation.
Small dosages are initially indicated in small and elderly patients and in those with renal or liver disease.
Doses over 75 mg do not increase therapeutic effects. Administer high doses with caution and closely observe patient for response.
Adult Dose25-50 mg PO q6-8h prn; not to exceed 300 mg/d
Pediatric Dose3 months to 12 years: 0.1-1 mg/kg PO q6-8h
>12 years: Administer as in adults
ContraindicationsDocumented hypersensitivity
InteractionsCoadministration with aspirin increases the risk of inducing serious NSAID-related side effects; probenecid may increase the concentrations and, possibly, toxicity of NSAIDs; may decrease the effect of hydralazine, captopril, and beta-blockers; may decrease the diuretic effects of furosemide and thiazides; may increase PT duration when taking anticoagulants (instruct patients to watch for signs of bleeding); may increase the risk of methotrexate toxicity; phenytoin levels may be increased when administered concurrently
PregnancyB - Fetal risk not confirmed in studies in humans but has been shown in some studies in animals
PrecautionsCategory D in third trimester of pregnancy; caution in patients with congestive heart failure, hypertension, and decreased renal and hepatic function; caution in the presence of anticoagulation abnormalities or during anticoagulant therapy

Drug NameNaproxen (Aleve, Naprosyn, Anaprox, Naprelan)
DescriptionFor relief of mild to moderate pain; inhibits inflammatory reactions and pain by decreasing activity of cyclooxygenase, which results in a decrease of prostaglandin synthesis.
Adult Dose500 mg PO followed by 250 mg q6-8h; not to exceed 1.25 g/d
Pediatric Dose<2 years: Not established
>2 years: 2.5 mg/kg/dose PO; not to exceed 10 mg/kg/d
ContraindicationsDocumented hypersensitivity; patients with peptic ulcer disease; recent GI bleeding or perforation; renal insufficiency
InteractionsCoadministration with aspirin increases the risk of inducing serious NSAID-related side effects; probenecid may increase the concentrations and, possibly, toxicity of NSAIDs; may decrease the effect of hydralazine, captopril, and beta-blockers; may decrease the diuretic effects of furosemide and thiazides; may increase PT duration when taking anticoagulants (instruct patients to watch for signs of bleeding); may increase the risk of methotrexate toxicity; phenytoin levels may be increased when administered concurrently
PregnancyB - Fetal risk not confirmed in studies in humans but has been shown in some studies in animals
PrecautionsCategory D in third trimester of pregnancy; acute renal insufficiency, interstitial nephritis, hyperkalemia, hyponatremia, and renal papillary necrosis may occur; patients with preexisting renal disease or compromised renal perfusion risk acute renal failure; leukopenia occurs rarely, is transient, and usually returns to normal during therapy; persistent leukopenia, granulocytopenia, or thrombocytopenia warrants further evaluation and may require discontinuation of drug.

Drug Category: Anesthetic (local) and corticosteroid combinations

Local anesthetics stabilize neuronal membranes and prevent the initiation and transmission of nerve impulses, thereby producing the local anesthetic action. Corticosteroids have anti-inflammatory properties and cause profound and varied metabolic effects. In addition, corticosteroids modify the body's immune response to diverse stimuli.

Drug NameCelestone and 1% lidocaine
DescriptionCompounded medication consisting of 0.5 mL of Celestone and 2.0 mL of 1% lidocaine without epinephrine.
Adult DoseOne-time injection into the area of the pes anserine bursa; repeat (if beneficial the first time); one time/y maximum
Pediatric DoseNot established
ContraindicationsDocumented hypersensitivity
InteractionsNone reported for this route of administration
PregnancyC - Fetal risk revealed in studies in animals but not established or not studied in humans; may use if benefits outweigh risk to fetus
PrecautionsCaution in the presence of bradycardia; caution if surrounding skin has decreased circulation



Return to Play

Athletes/patients may return to play or activities based upon their symptoms. In the more severe cases, restrictions on activities may be necessary. In athletes who play contact sports, the use of a protective pad over the affected area may prove useful.

Complications

A small risk of infection exists in recalcitrant cases in which the patient may have undergone an injection; however, if this procedure is performed properly under sterile conditions, the risk of infection is small.

Prevention

The best means to prevent pes anserine bursitis is to make sure that every athlete participates in a regular stretching program for the hamstring tendons.

Prognosis

By itself, pes anserine bursitis is usually a self-limiting condition, which has few long-term sequelae if the individual decides to try to participate in sports or activities and play through the pain. In most patients, a 6-8 week stretching and exercise program alleviates the symptoms.

Education

Educate patients, trainers, and coaches regarding a gradual increase in the patient's activity level and activity duration based on his or her symptoms.

For excellent patient education resources, visit eMedicine's Arthritis Center. Also, see eMedicine's patient education article Bursitis.



Medical/Legal Pitfalls

  • In patients whose symptoms last more than several months, consideration may be given to referring the patient to a specialist to ensure the correct diagnosis.
  • Obtain radiographs and an MRI to detect an underlying stress fracture or other bony or intra-articular abnormality or pathology.



Media file 1:  The pes anserine bursa is located on the proximomedial aspect of the tibia between the superficial medial (tibial) collateral ligament and the hamstring tendons (ie, sartorius, gracilis, semitendinosus). The pes anserine bursa serves as a space where motion occurs between these hamstring tendons and the underlying superficial tibial collateral ligament.
Click to see larger pictureClick to see detailView Full Size Image
Media type:  Photo



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Pes Anserine Bursitis excerpt

Article Last Updated: Oct 16, 2007