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Diabetes Resource Center
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Bullosis diabeticorum is a distinct, spontaneous, noninflammatory, blistering condition of acral skin unique to patients with diabetes mellitus. Krane first reported this condition in 1930; Cantwell and Martz are credited with naming the condition in 1967.
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Neuropathies are characterized by a progressive loss of nerve fibers that can be assessed noninvasively by several tests of nerve function, including nerve conduction studies and electromyography, quantitative sensory testing, and autonomic function tests. A widely accepted definition of diabetic peripheral neuropathy is "the presence of symptoms and/or signs of peripheral nerve dysfunction in people with diabetes after exclusion of other causes" (Boulton, 1998). Diabetic neuropathy is classified into several syndromes, each with a distinct pattern of involvement of peripheral nerves. Patients often have multiple or overlapping syndromes.
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Diabetic amyotrophy is a disabling illness distinct from other forms of diabetic neuropathy. Most commonly, onset is in middle age or later, although it may occur in youth. Concomitant distal, predominantly sensory, neuropathy may be present. Electrodiagnostic studies most often are consistent with neurogenic lesion attributable to lumbosacral radiculopathy, plexopathy, or proximal crural neuropathy.
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Diabetic foot ulcers occur as a result of a variety of factors. Such factors include mechanical changes in conformation of the bony architecture of the foot, peripheral neuropathy, and atherosclerotic peripheral arterial disease, all of which occur with higher frequency and intensity in the diabetic population.
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Type 1 Diabetes Mellitus Resource Center
Type 2 Diabetes Mellitus Resource Center |
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