You are in: eMedicine Specialties > Radiology > BRAIN/SPINE Rathke Cleft CystArticle Last Updated: Mar 27, 2008AUTHOR AND EDITOR INFORMATIONSection 1 of 10
  Author: Omar Islam, MD, FRCP(C), Assistant Professor of Radiology, Queen's University; Consulting Staff, Department of Imaging Services. Section Head, Division of Neuroradiology and Head & Neck Imaging, Kingston General Hospital and Hotel Dieu Hospital Omar Islam is a member of the following medical societies: American College of Radiology, American Society of Neuroradiology, Canadian Medical Association, College of Physicians and Surgeons of Ontario, Ontario Medical Association, Radiological Society of North America, and Royal College of Physicians and Surgeons of Canada Coauthor(s): Tariq Butt, MD; James Abrahams, MD, Director of Medical Studies, Associate Professor, Department of Diagnostic Radiology and Surgery, Division of Neuroradiology, Yale-New Haven Hospital, Yale University Editors: Pamela W Schaefer, MD, Assistant Professor of Radiology, Harvard Medical School; Associate Director of Neuroradiology, Clinical Director of Magnetic Resonance Imaging, Department of Radiology, Massachusetts General Hospital; Bernard D Coombs, MB, ChB, PhD, Consulting Staff, Department of Specialist Rehabilitation Services, Hutt Valley District Health Board, New Zealand; Robert L DeLaPaz, MD, Director, Professor, Department of Radiology, Division of Neuroradiology, Columbia University; Robert M Krasny, MD, Consulting Staff, Department of Radiology, The Angeles Clinic and Research Institute; James G Smirniotopoulos, MD, Professor of Radiology, Neurology, and Biomedical Informatics, Chairman, Department of Radiology and Radiological Sciences, Uniformed Services University of the Health Sciences Author and Editor Disclosure Synonyms and related keywords: Rathke's cleft cyst, RCC, benign epithelium-lined intrasellar cyst, Rathke pouch, Rathke's pouch INTRODUCTIONSection 2 of 10
  BackgroundRathke cleft cysts (RCCs) are benign, epithelium-lined intrasellar cysts believed to originate from remnants of the Rathke pouch. RCCs commonly have a round, ovoid, or dumbbell shape. In 1913, Goldzieher described the first case of RCC as an incidental postmortem finding. The description of RCC has expanded since the advent of computed tomography (CT) scanning and magnetic resonance imaging (MRI). PathophysiologyAs Voelker and colleagues have stated, the most common theory about the origin of RCCs is that the cysts are derived from true remnants of the embryologic Rathke pouch.1 On or about the 24th day of embryonic life, the Rathke pouch arises as a dorsal diverticulum from the stomodeum; it is lined with epithelial cells of ectodermal origin. At approximately the same time, the infundibulum forms as a downgrowth of the neuroepithelium from the diencephalon. By the fifth week, the Rathke pouch comes into contact with the infundibulum, and the neck of the pouch becomes occluded at the buccopharyngeal junction. During the sixth week, the Rathke pouch separates from the oral epithelium. Subsequently, the pars distalis of the pituitary gland develops from the anterior wall of the pouch. The posterior wall does not proliferate and remains as the poorly defined pars intermedia. The residual lumen of the pouch is reduced to a narrow Rathke cleft, which generally regresses. The persistence and enlargement of this cleft is considered to be the cause of the RCC. Other authors have different theories regarding the formation of RCCs, suggesting instead that the cells of origin are derived from the neuroepithelium or the endoderm, or that they come from metaplastic anterior pituitary cells. FrequencyUnited StatesAlthough not too infrequent, RCCs rarely cause symptoms. They have been reported in 2-26% of pituitary glands studied at autopsy.1 Mortality/MorbidityMortality associated with RCCs is extremely rare. In a study conducted by Shin and colleagues, the mortality rate was 0%, and the recurrence rate was 19%.2 In the literature, recurrence rates typically are lower, commonly 5-10%; however, Mukherjee co-authors reported a recurrence rate of 33%.3 Shin's study reported the cumulative rates of recurrence-free survival to be 85% at 5 years, 81% at 10 years, and 81% at 20 years. RaceNo race predilection is recognized. SexVoelker and colleagues reported a male-to-female ratio of 1:2.1 AgeThe patient's age at presentation ranges from 4-73 years (mean age, 38 y). The greatest frequency is in persons aged 50-60 years. AnatomyOn pathologic examination, the size of the cyst can vary from 2-40 mm. The cystic capsule frequently is described as thin and has been reported as being transparent, blue, gray, white, yellow, pink, red, tan, or green. The cystic fluid commonly is thick or gelatinous, but it also can be watery, serous, or similar in consistency to motor oil. The cystic fluid most often is yellow, but it also has been described as white, clear, gray, or green. At histologic examination, the cysts typically are composed of vascularized stroma of connective tissue and 3 types of epithelial cells: ciliated, nonciliated epithelial, and mucous secreting. Nonciliated cells appear as a single layer of flat cells or as stratified columnar cells. Fager and Carter concluded that the presence of ciliated epithelial and mucous-secreting cells in a pituitary gland is pathognomonic for RCC.4 In a retrospective analysis, Shin and co-authors found that all the RCCs studied were intrasellar in origin at their primary location.2 Because of their cystic nature, most of the RCCs that were studied expanded into the suprasellar cistern through the cleft of the diaphragma sella. In Voelker's report, a retrospective study of 155 patients with symptomatic RCC, the cyst was found in intrasellar and suprasellar locations in 71% of the patients.1 The sella was enlarged in 80%. Clinical DetailsRCCs often produce no symptoms and so are usually discovered incidentally, when radiographic or necropsy findings are reviewed. Most cysts are smaller than 2 cm in diameter. Symptomatic RCCs are uncommon, but cysts can enlarge and cause symptoms secondary to compression of the pituitary gland, pituitary stalk, optic chiasm, or hypothalamus. Symptomatic RCCs vary in presentation. In a study of 11 symptomatic patients by Rao and colleagues, 8 patients initially had visual symptoms.5 In another study, by Eguchi and co-authors, visual symptoms occurred in 47% of patients.6 Signs and symptoms included reduced visual acuity, optic atrophy, visual field defects, and a chiasmatic syndrome. Eguchi's study looked at 19 patients, 4 of whom had diabetes insipidus, 3 of whom had amenorrhea and/or galactorrhea, and 2 of whom had panhypopituitarism. With systematic endocrinologic examinations, various degrees of pituitary dysfunction were observed. Other abnormal findings included headaches and, less commonly, epilepsy. In the study by Voelker and colleagues, the most common finding was pituitary hypofunction with multiple endocrinopathies.1 Younger patients, aged 4-22 years, had evidence of hypopituitarism from an early age, with resultant growth retardation. The second most common symptom was visual disturbance, which included visual field defects resulting from chiasmatic compression. The next most common symptom was headache, of which 57% were frontal. Shin and co-authors described impotence or low libido as the most common endocrine abnormality in men; in women, the most common was hyperprolactinemia. Many RCCs are associated with pituitary adenomas.2 In addition to the symptoms described above, endocrine symptoms occur as a result of the adenoma. Other unique or unusual findings associated with RCC include pituitary apoplexy, hypophysitis, giant cysts, large frontal extension with an unusual shape, aseptic meningitis, intracystic abscess, sphenoid sinusitis, and empty sella syndrome.7, 8, 9, 10, 11 Preferred ExaminationMRI is the modality of choice in the detection of RCCs.12 Thin-section sagittal and coronal MRI scans should be obtained through the sella. CT scans are also useful for evaluating RCCs. They are particularly helpful in delineating associated bony remodeling and in assessing calcification. Limitations of TechniquesMRI is superior to CT scanning for evaluating RCC mass extension. Sagittal and coronal MRI scans provide reliable information concerning the relationship of the mass to the optic nerves, optic chiasm, and hypothalamus. Coronal MRI is also helpful in the evaluation of the lateral extension of the sellar cyst and its relationship to the internal carotid arteries and cavernous sinuses. MRI also has superior multiplanar capabilities and contrast resolution compared with those of CT scanning. The advantage of CT scanning is that it is superior to MRI in depicting small amounts of calcium. This advantage can be important, because the presence of calcification tends to indicate an alternative diagnosis, such as craniopharyngioma, although small calcifications are observed in some cases of RCC.13 CT scanning is also superior to MRI in the evaluation of associated bony remodeling. DIFFERENTIALSSection 3 of 10
Arachnoid Cyst Craniopharyngioma Cysticercosis, CNS Epidermoid, Brain Pituitary Adenoma Other Problems to Be ConsideredWhen an intrasellar cystic mass is present, consider empty sella, intrasellar aneurysm, and mucocele. RADIOGRAPHSection 4 of 10
FindingsRCCs usually do not enlarge the sella turcica on plain skull radiographs. This finding is consistent with the fact that most RCCs are asymptomatic because of their small size and, hence, their lack of adjacent bone involvement. In patients with symptomatic RCCs, plain skull radiographs commonly demonstrate an abnormally configured sella, with variations ranging from slight asymmetry of the sellar floor to massive erosion. In some patients, intrasellar and/or suprasellar calcification is observed. Degree of ConfidenceThe degree of confidence in radiographic findings in the diagnosis of RCC is poor. The limited findings are not specific to RCCs, because other common sellar phenomenon can have the same characteristics as those of an abnormal sellar configuration and/or displacement. False Positives/NegativesBecause RCCs cannot and should not be diagnosed without performing all of the relevant diagnostic studies, the issue of false-positive and false-negative findings is not applicable. CT SCANSection 5 of 10
FindingsRCCs frequently appear as well-circumscribed, hypo-attenuating, cystic sellar masses that may have suprasellar extension.12 As a result of the different cystic contents, RCCs may appear iso-attenuating or hyperattenuating relative to the brain parenchyma. RCCs usually have a thin wall that may enhance. Variability in CT scan contrast enhancement among individual cysts may reflect squamous metaplasia in the wall or a peripherally displaced rim of pituitary tissue. Extravasation of cystic contents may inflame nearby structures, resulting in enhancement. Calcification characteristically is not depicted on CT scans, although Shin and colleagues have described this finding in a number of cases.2 Complex cysts may have septations. Large cysts may cause bony remodeling. Degree of ConfidenceAs a result of the variability in presentation, the clinician cannot use CT scan findings alone to support a definite diagnosis, nor can the findings positively exclude a pathologic condition similar to RCC. Simple cysts may be indistinguishable from arachnoid cysts or epidermoids. More complex cysts may be indistinguishable from a craniopharyngioma or pituitary adenoma. For this reason, definite diagnosis must be supported by clinical, biochemical, pathologic, and other radiographic findings. False Positives/NegativesSimple cysts may be indistinguishable from arachnoid cysts or epidermoids. More complex cysts may be indistinguishable from a craniopharyngioma or pituitary adenoma. MRISection 6 of 10
FindingsMRI appearances of RCCs are highly variable.12, 14 Although no characteristic MRI features have been identified, many RCCs are in 1 of the following 2 groups:
The cystic contents of the first group resemble those of cerebrospinal fluid (CSF). In the second group, an increase in the signal on T1-weighted images has been related to the high content of mucopolysaccharides, which is believed to result from an increase in the number of mucin-secreting cells in the cyst wall, as well as from an increase in the activity of these cells. Uncommon cases with high signal intensity on T1-weighted images and low signal intensity on T2-weighted images have been suggested to result from a combination of factors, including the presence of mucopolysaccharides, chronic hemorrhage, a high cholesterol content, and cellular debris from the cyst wall. RCCs almost always are homogeneous in signal intensity, whereas other lesions, such as cystic craniopharyngiomas and hemorrhagic adenomas, more frequently have heterogeneous signal intensity.15 RCCs usually have a thin wall that may enhance with gadolinium-based contrast material. Variability in the gadolinium enhancement among individual cysts may reflect squamous metaplasia in the wall or a peripherally displaced rim of pituitary tissue. Reports about the cystic intensity of RCCs and their clinical manifestations have been rare. In 1997, Takeichi and colleagues examined 78 patients, including 9 of their own, and reported that RCCs with CSF-like signal intensity were slow growing and large and that they frequently caused visual disturbances. RCCs with other signal intensities were smaller when they caused clinical symptoms.16, 17 Gadolinium-based contrast agents (gadopentetate dimeglumine [Magnevist], gadobenate dimeglumine [MultiHance], gadodiamide [Omniscan], gadoversetamide [OptiMARK], gadoteridol [ProHance]) have recently been linked to the development of nephrogenic systemic fibrosis (NSF) or nephrogenic fibrosing dermopathy (NFD). For more information, see the eMedicine topic Nephrogenic Fibrosing Dermopathy. The disease has occurred in patients with moderate to end-stage renal disease after being given a gadolinium-based contrast agent to enhance MRI or magnetic resonance angiography (MRA) scans. Degree of ConfidenceNo characteristic pattern of MRI signal intensity can be used to reliably differentiate RCCs from other cystic sellar or suprasellar lesions. Simple cysts may be indistinguishable from arachnoid cysts or epidermoids. More complex cysts may be indistinguishable from a craniopharyngioma or pituitary adenoma. As a result of varying CT scan and MRI findings, a combination of clinical, biochemical, and radiographic findings must be used to establish a diagnosis of RCC before surgery.14 The differentiation is important, because treatment and surgical modalities for RCC are different from those for other possible entities. False Positives/NegativesSimple cysts may be indistinguishable from arachnoid cysts or epidermoids. More complex cysts may be indistinguishable from a craniopharyngioma or pituitary adenoma. ANGIOGRAPHYSection 7 of 10
FindingsVoelker and co-authors performed cerebral angiography in 39 patients and detected findings in 32.1 The primary abnormality was an avascular mass effect with an elevation of the A1 segments of the anterior cerebral arteries. INTERVENTIONSection 8 of 10
The most common approach in the treatment of RCCs is transsphenoidal surgery, in which the cyst is partially excised and drained.20, 21 This method is effective and helps to preserve pituitary function. Radical excision can cause additional and unnecessary pituitary damage; therefore, it is not the treatment of choice. In transsphenoidal surgery, the cyst is opened, a biopsy specimen is obtained from the wall, and the cyst is drained into the sphenoid sinus. No sellar reconstruction is needed unless a CSF leak is noted during surgery. In patients in whom this approach is not appropriate because of an inaccessible cyst, craniotomy is performed, usually via a right frontal flap. In some patients, the postoperative follow-up period ranges from 1 week to 26 years (average, 34 mo). The postoperative outcome for most patients is resolution of or improvement in symptoms. In patients with hypopituitarism or diabetes insipidus, the RCC usually fails to improve. After surgery, the greatest improvement in symptoms occurs with a resolution of neurologic symptoms (71% of patients), followed a resolution of ophthalmologic symptoms (70% of patients). In more than 65% of patients, amenorrhea, galactorrhea, and oligomenorrhea improve. Headaches and visual field defects resolve in 82% and 70% of patients, respectively. Surgical complications include CSF rhinorrhea (7% of patients), diabetes insipidus (4% of patients), and meningitis (4% of patients). A rare surgical complication noted by Baskin was nasal septal perforation.22 Abscess formation in a cyst is a treatable complication; this complication should be considered even in the absence of fever when radiologic features suggest the condition. Treatment with surgery and antibiotic medications is effective in most patients. The recurrence rate after craniotomy is twice as high as that after transsphenoidal surgery. In addition, leakage of the cystic contents into the subarachnoid space has been reported; this can cause aseptic meningitis. In cases of recurrence, extensive removal of the cyst wall is most appropriate, and some recommend external beam pituitary radiation therapy, although its role in preventing further recurrence remains unclear. Fager and Carter recommend full evacuation of the cystic contents and liberal opening of the wall in the treatment of symptomatic RCCs.4 When this procedure is performed, recurrence is rare. An interesting aspect of treatment is the decrease in the size of the cyst after high-dose steroid therapy. Although the pathophysiologic mechanism is not clear, the steroids are assumed to have an effect on the secretion or absorption of cystic fluid. This finding suggests that steroid therapy may be useful in some patients with an RCC and inflammatory changes. Further study in this area is needed to gauge its effectiveness is the treatment of RCCs. MULTIMEDIASection 9 of 10
REFERENCESSection 10 of 10
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