Excerpt from Wound Healing, Growth Factors
Synonyms, Key Words, and Related Terms: primary healing, wound closure, secondary healing, re-epithelialization, reepithelialization, tertiary wound closure, delayed primary closure, debridement, suture, inflammatory phase, proliferative phase, maturational phase, hemostasis, inflammation, collagen, clotting cascade, clotting, thromboxane A2, prostaglandin 2a, prostaglandin 2-alpha, vasoconstrictor, hemorrhage, vasodilatation, histamine, platelet, chemokine, epidermal growth factor, EGF, fibronectin, fibrinogen, histamine, platelet derived growth factor, platelet-derived growth factor, PDGF, serotonin, von Willebrand factor, clot formation, platelet degranulation, complement cascade, neutrophil, leukocyte, macrophage, monocyte, collagenase, interleukin, tumor necrosis factor, TNF, fibroblasts, transforming growth factor, TGF, keratinocyte, epithelialization, angiogenesis, granulation tissue formation, collagen deposition, insulin-like growth factor, insulinlike growth factor
Tremendous advancements have been made in understanding the processes of wound healing. The cell types and the order in which they appear in the wound have been established; many growth factors and their functions have been elucidated. Despite the advances in understanding the science of wound healing, many more steps have yet to be discovered and elucidated. The frontier of this field includes the prevention of hypertrophic and keloid scar formation and, ultimately, any visual remnant of the wound.
An incision created by a scalpel, trauma resulting from a bullet, or tissue death caused by a myocardial infarction all undergo a similar and predictable reparative process. Understanding how the body repairs damaged tissue and what factors influence the wound healing process helps the surgeon ensure an acceptable outcome from surgery.
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