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Author: Jeffrey M Donohoe, MD, Assistant Professor of Pediatric Urology, Department of Surgery, Division of Urology, Medical College of Georgia

Jeffrey M Donohoe is a member of the following medical societies: American Academy of Pediatrics and American Urological Association

Coauthor(s): James A Brown, MD, FACS, Associate Professor, Department of Surgery, Medical College of Georgia; Consulting Staff, Head of Urologic Oncology, Veterans Affairs Medical Center; Subbarao V Cherukuri, MD, Consulting Staff, Department of Urology, St Joseph Regional Health Center

Editors: Michael Grasso, MD, Chairman, Department of Urology, Saint Vincent's Medical Center; Professor and Vice Chairman, Department of Urology, New York Medical College; Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine; Martin I Resnick, MD †, Former Lester Persky Professor and Chair, Department of Urology, Former Professor, Department of Oncology, Case Western Reserve University School of Medicine; J Stuart Wolf, Jr, MD, FACS, David A Bloom Professor of Urology, Director, Division of Minimally Invasive Urology, Department of Urology, University of Michigan Medical Center; Stephen W Leslie, MD, FACS, Founder and Medical Director of the Lorain Kidney Stone Research Center, Clinical Assistant Professor, Department of Urology, Medical College of Ohio

Author and Editor Disclosure

Synonyms and related keywords: ureteral calculus removal by open surgery

Ureterolithotomy refers to the open surgical removal of a stone from the ureter. Open ureterolithotomy has become very rare within the last decade due to the advent of less invasive procedures such as extracorporeal shock wave lithotripsy [ESWL] treatment and ureteroscopic stone removal or fragmentation. Less invasive procedures for ureteral stones include ureteroscopic stone basket extraction under direct vision and destruction of the calculus by various means, including electrohydraulic lithotripsy (EHL), ultrasound, pneumatic contact lithotripsy (Lithoclast), as well as lasers such as the pulsed dye and holmium. However, open ureterolithotomy still has a role where such sophisticated modalities are lacking, when other therapies have failed, and in cases involving significant ureteral strictures requiring open surgical repair.

History of the Procedure

In 1882, Bardenheuer removed a calculus from the upper ureter using an open surgical technique. This represents one of the earliest recorded cases of ureterolithotomy.

Problem

Stones that result in complete obstruction of the ureter, causing severe pain, fever, and urosepsis, require treatment that includes prompt, appropriate drainage (eg, ureteral stent, percutaneous nephrostomy) and subsequent definitive stone removal. Open ureterolithotomy has finite indications and is employed most commonly when minimally invasive therapies have failed.

Frequency

Ureterolithotomy (open surgical removal of the stone from the ureter) is performed rarely at present; however, it continues to be considered when other modalities, such as ESWL, ureteroscopy with laser, EHL, or ultrasound, fail.

Etiology

Most ureteral stones form in the kidney and migrate in to the ureter. Many stones are passed spontaneously. Stones larger than 10 mm are unlikely to be passed. Most urologists have noted that some small stones often require surgical intervention, perhaps due to irregular margins of the stone. Passage of stones commonly is stopped at the narrow areas of the ureter, in the proximal ureter at the ureteropelvic junction, in the mid ureter where the ureter crosses the iliac vessels, and in the lower ureter at the ureteropelvic junction.

Clinical

Ureteral stones often present as renal colic. Pain radiates in to the groin or testicle. Pain is either constant or intermittent. Pain varies from severe to a dull ache. Pain on the left side is much more common. Ureteral stones are more frequent in men. Urinalysis most often is positive for occult blood. Results on physical examination may be normal except for some costovertebral angle tenderness.



Although open ureterolithotomy has become very rare within the last decade because of the advent of extracorporeal and intracorporeal lithotripsy, it still has a role where such sophisticated modalities are lacking, when other therapies have failed, and in cases involving significant ureteral strictures requiring open surgical repair.

Conservative treatment is possible for stones smaller than 5 mm. Pain, infection, and associated anatomical abnormalities on occasion necessitate surgical intervention in smaller stones.

First-line surgical intervention involves minimally invasive procedures. Depending on the location of the stone, experience of the urologist, and preference of the patient, either extracorporeal shock wave lithotripsy (ESWL) or ureteroscopy and intracorporeal lithotripsy are instituted. With the miniaturization of scopes and use of sophisticated wires, dilators, access sheaths, and stents, even cases involving complicated stones (ie, stricture with impacted stone) can be approached with ureteroscopy. Even in cases in which patients present with sepsis and hydronephrosis due to an impacted stone, the preferred treatment is percutaneous drainage of the kidney with nephrostomy and delayed endoscopic treatment of the stone. However, in cases that involve failure or other extenuating circumstances, open ureterotomy can be performed.



A ureter is 20-27 cm in length and 5-7 mm in diameter. The narrow parts in the ureter are at the ureteropelvic junction, in the most cephalad part; in the middle, where the ureter crosses the iliac vessels; and in the most caudal part, at the ureterovesical junction (intramural part of ureter).

In men, the vas deferens crosses the ureter at its lower one third anteriorly. In women, the round ligament crosses the ureter at its lower one third anteriorly. The ureter is adjacent to the gonadal vessels.

Periureteral vessels, from the pelvic branch of the renal artery, provide the blood supply to the ureter in the upper one third. In the lower one third, the vesicle artery supplies blood. The middle third is supplied by the lumbar vessels; here the blood supply is precarious. During ureterolithotomy, stripping the ureter of its periureteral fat in the middle third has to be performed very carefully.

The urine in the ureter progresses due to peristalsis, and the nerve plexus that runs along the ureter controls peristalsis.



This procedure is not contraindicated unless the patient is in poor general condition. Consider ureterolithotomy as a last resort. Consider noninvasive procedures, such as ESWL, and less invasive ureteroscopy first.



Lab Studies

  • Obtain CBC count, urine culture, BUN, creatinine, and prothrombin time.

Imaging Studies

  • A plain radiograph obtained preoperatively is strongly advised because stones often change position and even may be passed.
  • Because most stones in the plain radiograph of the kidneys, ureters, and bladder (KUB) are radiopaque, they can be visualized in the course of the ureter.
  • However, intravenous pyelogram (IVP) is an effective means of assessing function and stone position, as well as distinguishing stones from the phleboliths. At times, oblique films and delayed pictures may have to be obtained.
  • Sonography is a useful modality.
  • CT scan detects smaller stones and other causes of abdominal pain. Scans are performed with no dye. CT scans reveal nonopaque stones as well, but renal function cannot be assessed adequately. Also, CT scan is very expensive, so its use is limited to some complicated cases.

Other Tests

  • Obtaining ECG, chest radiograph, and preoperative radiograph of KUB to visualize the position of the stone in the ureter is advisable.



Medical therapy

Conservative treatment is possible for stones smaller than 5 mm. Pain, infection, and associated anatomical abnormalities on occasion necessitate surgical intervention in smaller stones.

Surgical therapy

  • Goals of ureterolithotomy are to remove all stones and fragments, to correct the anatomical abnormalities, and to avoid causing a ureteral stricture or any other new problem.
  • Surgical therapy depends on the site of the stone in the ureter—upper third, middle third, or lower third.
  • Sterile urine is preferable; administer an appropriate preoperative antibiotic with broad-spectrum activity, such as ciprofloxacin.
  • Radiograph of KUB: Prior to the operation, stones can move, and surgical strategies vary with the position of the stone. Knowing the precise location immediately before the surgery is essential.
    • Stones move cephalad mostly due to the dilated ureter.
    • On occasion, due to peristalsis, stones move distally as well.
    • Not finding a stone at open ureterolithotomy is disturbing for the surgeon and the patient.

Upper and middle ureterolithotomy

  • Incision is at the 12th rib or is subcostal. Incision is from over the distal third of the 12th rib, extending 6-8 cm anteriorly towards the umbilicus.
  • Jack-knife kidney position with the table flexed is preferable. Kidney rest may be raised.
  • Insert a urethral Foley catheter
  • Cystoscopy and insertion of a stent are useful in draining the kidney and also are useful in easily recognizing the ureter and preventing the fragments from downward migration and blockage.
  • The ribs do not need to be resected.
  • Protect the subcostal nerve.
  • Cut the external and internal obliques and the transversalis with the diathermy current with fingers pushing the peritoneum. Push the peritoneum anteriorly.
  • Identify the ureter and dissect the serosa and periureteral fat. To avoid compromising the blood supply, do not be overzealous.
  • Feel the stone in the ureter between the fingers and visualize the bulge in the ureter. When in doubt, aspirate with a 22-gauge needle and 5-cc syringe.
  • Immobilize the stone with 2 vascular loops above and below the stone.
  • Cut over the stone with a knife vertically.
  • Remove the stone.
  • Irrigate the ureterolithotomy site and then irrigate proximally and distally with a rubber catheter. Palpate to ensure no other stone fragments are present.
  • If a stent is needed, insert a double J proximally first and then distally. Fluoroscopy is very helpful in locating the proximal and distal ends of the stent for proper positioning. If fluoroscopy is not available, install indigo carmine into the bladder via Foley catheter. The dye should come through the stent at the ureterolithotomy site if stent is in bladder.
  • Close the ureterolithotomy site with 4-O chromic interrupted sutures. Watertight closure is not necessary.
  • Confine bite to the serosal layer and do not cause stricture. If the edges are not approximated easily or when in doubt, stent the ureter with a double J and do not close the ureterolithotomy site.
  • Drain the ureterolithotomy site through a stab incision with a soft Penrose or a suction drain.
  • Irrigate the wound with warm water.
  • Close the incision with synthetic absorbable interrupted sutures in 2 layers.
  • Close the skin with absorbable sutures or surgical staples.
  • Fix the drain with a suture.
  • Instillation of Marcaine 0.25% or 0.5% may be beneficial for postoperative pain.

Lower ureterolithotomy

  • Lower ureterolithotomy is much more difficult than upper and middle third ureterolithotomies.
  • Obtaining an x-ray of KUB to evaluate the precise location and number of stones is mandatory.
  • Drain the bladder with a Foley catheter.
  • Perform an oblique muscle-splitting Gibson incision in the lower quadrant ipsilateral to the stone. Split all 3 muscles in the line of the incision. Once the peritoneum is reached, push it medially and remain in the retroperitoneum.
  • Cut the muscles with the diathermy current.
  • Push the peritoneum medially from the inguinal ligament.
  • Identify the ureter when crossing the iliac vessels and put it on a vessel loop.
  • Dissect the ureter towards the bladder.
  • The vas deferens in men and the uterine artery in women cross the ureter.
  • Stabilize the ureter above and below with the vessel loops.
  • Perform ureterotomy over the stone and remove the stone.
  • Irrigate the upper and lower ureter.
  • Drain the ureterolithotomy site.
  • Close the ureterolithotomy site with interrupted 4-O chromic sutures.
  • Close the incision in 2 layers with a synthetic absorbable interrupted suture.
  • Close the skin with staples and 3-O nylon suture the drain.

Intraoperative details

Stabilize the ureter between 2 umbilical tapes and perform a generous ureterotomy so that the stone can be removed easily. After removal of the stone(s), initially pass a number 8 red rubber catheter proximally and irrigate so that any remaining stone fragments can be flushed out. Then pass the catheter distally and flush the ureter of any fragments. Watertight closure of the ureterotomy is advisable, taking care not to constrict the ureter. Always drain the ureterotomy site with a Penrose drain or JP (vacuum) drain. Make sure the stone is sent for chemical analysis to determine the composition of the stone, which helps in stone prevention therapy and advice.

Postoperative details

Mobilize the patient on the day of surgery from bedrest as soon as possible. Remove the drain after 5 days if the drainage is scanty. Remove the urethral Foley catheter after the second day.

Follow-up

An IVP 3-6 months postoperatively is helpful in recognizing stricture or residual stones.

Patients should be evaluated for chemical risk factors that lead to stone formation. This should include an analysis of the chemical composition of the stone and an evaluation of the patient's diet. Minimum metabolic studies for stone prevention analysis are essential for determining the underlying risk factors for new stone formation. A minimal study should include serum electrolytes, calcium, creatinine, bicarbonate, and uric acid together with a 24-hour urine collection with analysis of calcium, uric acid, citrate, oxalate, sodium, magnesium, and volume. Appropriate preventive measures then can be instituted.

For excellent patient education resources, visit eMedicine's Kidneys and Urinary System Center. Also, see eMedicine's patient education articles Kidney Stones and Intravenous Pyelogram.



Early complications

  • Bleeding due to unrecognized injury to adjacent gonadal vessels or inferior vena cava is a possible early complication.
  • Persistent urinary leak may be due to urinary fistula. If no distal obstruction is present, treat urinary fistula conservatively or with an indwelling stent inserted via cystoscope. Occasionally, percutaneous nephrostomy may be needed.

Late complications

  • Ureteral stricture can be recognized due to persistent hydronephrosis and a narrow area on the IVP.
  • Treatment of residual stones depends on size and location of stones. Ureteroscopy and removal of the stone fragment may be needed.



  • Migration of the stone
  • Urinary leak and extravasation may not cause problems if the wound is drained. Most leaks heal in 3 weeks. If urinary leak is persistent, rule out distal obstruction via CT scan or IVP.
  • If the obstruction can be removed by cystoscopy, remove it and insert a stent. If the obstruction is due to a mass or a stricture, drain the kidney by means of nephrotomy, and passing a stent from above into the bladder may be possible.
  • Ureterolithotomy continues to be useful. It is used rarely in developed countries, but it is a mainstay of treatment in the rest of the world.



Laparoscopic ureterolithotomy has been described as a means of treating complex, often particularly large, ureteral calculi that are not amenable to more standard minimally invasive therapies.



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Ureterolithotomy excerpt

Article Last Updated: Sep 13, 2006