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Emergency Medicine > TRAUMA AND ORTHOPEDICS
Dislocations, Knee
Article Last Updated: Nov 29, 2007
AUTHOR AND EDITOR INFORMATION
Section 1 of 11
Author: Diku Mandavia, MD, FACEP, FRCPC, Attending Staff Physician, Department of Emergency Medicine, Cedars-Sinai Medical Center; Clinical Associate Professor of Emergency Medicine, Los Angeles County-USC Medical Center; Co-Editor, Color Atlas of Emergency Trauma
Editors: James E Keany, MD, FACEP, Medical Director, JetWest International Air Ambulance, Van Nuys, California; Consulting Staff, Department of Emergency Services, Mission Hospital Regional Medical Center, Mission Viejo, California; Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine; Tom Scaletta, MD, President, American Academy of Emergency Medicine; Chairperson, Department of Emergency Medicine, Edward Hospital; Assistant Professor of Emergency Medicine, Rush Medical College/Cook County Hospital; John Halamka, MD, Chief Information Officer, CareGroup Healthcare System, Assistant Professor of Medicine, Department of Emergency Medicine, Beth Israel Deaconess Medical Center; Assistant Professor of Medicine, Harvard Medical School; Barry E Brenner, MD, PhD, FACEP, Program Director, Department of Emergency Medicine, University Hospitals, Case Medical Center
Author and Editor Disclosure
Synonyms and related keywords:
knee dislocation, dislocated knee, anterior dislocation, posterior dislocation, medial dislocation, lateral dislocation, rotatory dislocation, open dislocation, closed dislocation, popliteal artery injury, knee hyperextension, trauma to the knee
Background
Knee dislocation is a relatively rare injury but an important one to recognize because coexistent vascular injury, if missed, often leads to limb loss. In addition, knee dislocation often presents in the context of multisystem trauma or spontaneous relocation, which makes detection more difficult.
History
Knee dislocation is classified according to the position of the tibia relative to the femur. The 5 major types of dislocation, which are illustrated in Media file 1, are as follows:
- Anterior: Anterior dislocation often is caused by severe knee hyperextension. Cadaver research has shown that approximately 30 degrees of hyperextension is required before dislocation will occur.
- Posterior: Posterior dislocation occurs with anterior-to-posterior force to the proximal tibia, such as a dashboard type of injury or a high-energy fall on a flexed knee. Media file 2 shows a radiograph of a posterior dislocation.
- Medial, lateral, or rotatory: Medial, lateral, and rotatory dislocations require varus, valgus, or rotatory components of applied force. A lateral dislocation is illustrated in Media file 3.
- More than half of all dislocations are anterior or posterior, and both of these have a high incidence of popliteal artery injury. Twenty to thirty percent of all knee dislocations are complicated further by open joint injury (see Media file 4).
Physical
- Most often, the affected limb has a gross deformity around the knee with swelling and immobility. Occasionally, the knee will have relocated spontaneously prior to the patient's arrival at the ED. This makes a careful physical examination very important. The finding of varus or valgus instability in full extension of the knee is suggestive of a grossly unstable knee and of a spontaneously reduced dislocation. In addition, pain out of proportion or absent or decreased pulse should be red flags of such an injury. The above also underscores the importance of joint and vascular examinations, especially in patients with head injuries or in those who are intoxicated and may not be able to communicate symptoms adequately.
- A careful vascular examination is essential, as popliteal artery injury occurs in 7-45% of all knee dislocations. The popliteal artery may be damaged severely in both closed and open dislocations, and such injury must be ruled out in knees that have relocated spontaneously. Palpation of the dorsalis pedis and posterior tibial arteries along with capillary refill evaluation is necessary. The presence of normal pulses does not rule out the presence of significant vascular injury. Coexistent peroneal nerve injury occurs in 25-35% of patients and manifests with decreased sensation at the first webspace with impaired dorsiflexion of the foot.
Causes
- The knee is a very stable joint requiring high-energy trauma to produce dislocation. At least 3 major ligaments must rupture for dislocation to occur. Common mechanisms of injury include the following:
- Motor vehicle collisions
- Auto-pedestrian impact
- Industrial injuries
- Falls
- Athletic injuries
Fractures, Femur
Fractures, Knee
Fractures, Tibia and Fibula
Imaging Studies
- Plain radiographs
- Arteriogram
- Duplex scanning
- Ankle-brachial index
Prehospital Care
- Prehospital personnel should splint the extremity and provide rapid transport to a medical facility.
- Perform field reduction for patients with evidence of vascular compromise.
Emergency Department Care
- Reduction procedures
- Do not delay reduction in limbs with obvious vascular impairment. Only patients with good peripheral pulses should undergo prereduction radiographs.
- Reduction is straightforward and often easily accomplished in the ED. After adequate sedation, longitudinal traction will relocate the majority of knee dislocations. A postreduction lateral knee dislocation is shown in Media file 5. Posterolateral dislocations are particularly difficult and often require operative reduction.
- After reduction, splint the lower extremity, apply ice, and keep the knee elevated.
Consultations
Always consult an orthopedic surgeon. In addition, strongly consider consulting a vascular surgeon, as many patients have significant vascular injury.
NSAIDs, analgesics, and anxiolytics are used to treat the pain associated with dislocations.
Drug Category: Analgesics
Pain control is essential to quality patient care. It ensures patient comfort, promotes pulmonary toilet, and aids physical therapy regimens. Many analgesics have sedating properties that benefit patients with injuries.
| Drug Name | Fentanyl citrate (Duragesic, Sublimaze) |
| Description | Narcotic analgesic with greater potency and much shorter half-life than morphine sulfate. Excellent choice for pain management and sedation with its short duration time (30-60 min) and ease of titration. Easily and quickly reversed by naloxone. After initial dose, subsequent doses should not be titrated more frequently than q3h or q6h. |
| Adult Dose | 0.5-1 mcg/kg/dose IV/IM q30-60min |
| Pediatric Dose | <2 years: 2-3 mcg/kg/dose IV/IM q30-60min 2-12 years: 1-2 mcg/kg/dose IV/IM q60min >12 years: Administer as in adults |
| Contraindications | Documented hypersensitivity; hypotension; potentially compromised airway in which establishing rapid airway control would be difficult |
| Interactions | Phenothiazines may antagonize analgesic effects; tricyclic antidepressants may potentiate adverse effects |
| Pregnancy | C - Fetal risk revealed in studies in animals but not established or not studied in humans; may use if benefits outweigh risk to fetus
|
| Precautions | Caution in hypotension, respiratory depression, constipation, nausea, emesis, and urinary retention; idiosyncratic reaction, known as chest wall rigidity syndrome, may require neuromuscular blockade to increase ventilation |
| Drug Name | Meperidine (Demerol) |
| Description | Narcotic analgesic with multiple actions similar to those of morphine. May produce less constipation, smooth muscle spasm, and depression of cough reflex than similar analgesic doses of morphine. |
| Adult Dose | 50-150 mg PO/IV/IM/SC q3-4h prn |
| Pediatric Dose | 1-1.8 mg/kg (0.5-0.8 mg/lb) PO/IV/IM/SC q3-4h prn; not to exceed adult dose |
| Contraindications | Documented hypersensitivity; concurrent MAOIs; upper airway obstruction or significant respiratory depression; during labor when delivery of premature infant is anticipated |
| Interactions | Cimetidine may increase respiratory and CNS depression; hydantoins may decrease effects; avoid with protease inhibitors |
| Pregnancy | C - Fetal risk revealed in studies in animals but not established or not studied in humans; may use if benefits outweigh risk to fetus
|
| Precautions | Caution in patients with head injuries, since meperidine may increase respiratory depression and CSF pressure (use only if absolutely necessary); caution when using postoperatively and with history of pulmonary disease (suppresses cough reflex); substantially increased dose levels, due to tolerance, may aggravate or cause seizures even if no prior history of convulsive disorders; monitor closely for meperidine-induced seizure activity if prior seizure history |
| Drug Name | Oxycodone and acetaminophen (Percocet) |
| Description | Drug combination indicated for relief of moderately severe to severe pain. DOC for aspirin-hypersensitive patients. |
| Adult Dose | 1-2 tab or cap PO q4-6h prn |
| Pediatric Dose | 0.05-0.15 mg/kg/dose oxycodone PO q4-6h prn; not to exceed 5 mg/dose of oxycodone |
| Contraindications | Documented hypersensitivity |
| Interactions | Phenothiazines may decrease analgesic effects; CNS depressants or tricyclic antidepressants may increase toxicity |
| Pregnancy | C - Fetal risk revealed in studies in animals but not established or not studied in humans; may use if benefits outweigh risk to fetus
|
| Precautions | Duration of action may increase in elderly; be aware of total daily dose of acetaminophen patient is receiving; do not exceed 4,000 mg/24 h of acetaminophen; higher doses may cause liver toxicity |
| Drug Name | Acetaminophen and codeine (Tylenol #3) |
| Description | Drug combination indicated for treatment of mild to moderately severe pain. |
| Adult Dose | 30-60 mg/dose based on codeine content PO q4-6h or 1-2 tab q4h; not to exceed 12 tabs/d |
| Pediatric Dose | 0.5-1 mg/kg/dose based on codeine content PO q4-6h; 10-15 mg/kg/dose based on acetaminophen content; not to exceed 2.6 g/d of acetaminophen |
| Contraindications | Documented hypersensitivity |
| Interactions | CNS depressants or tricyclic antidepressants may increase toxicity |
| Pregnancy | C - Fetal risk revealed in studies in animals but not established or not studied in humans; may use if benefits outweigh risk to fetus
|
| Precautions | Caution in patients dependent on opiates, since this substitution may result in acute opiate-withdrawal symptoms; caution in severe renal or hepatic dysfunction |
| Drug Name | Hydrocodone bitartrate and acetaminophen (Vicodin ES) |
| Description | Drug combination indicated for relief of moderately severe to severe pain. |
| Adult Dose | 1-2 tab or cap PO q4-6h prn pain |
| Pediatric Dose | <12 years: 10-15 mg/kg/dose acetaminophen PO q4-6h prn; not to exceed 2.6 g/d acetaminophen or 5 mg of hydrocodone bitartrate/dose >12 years: 750 mg acetaminophen PO q4h; not to exceed 5 doses/d acetaminophen or 10 mg of hydrocodone bitartrate/dose |
| Contraindications | Documented hypersensitivity; high-altitude cerebral edema; elevated intracranial pressure |
| Interactions | Phenothiazines may decrease analgesic effects; CNS depressants or tricyclic antidepressants may increase toxicity |
| Pregnancy | C - Fetal risk revealed in studies in animals but not established or not studied in humans; may use if benefits outweigh risk to fetus
|
| Precautions | Tablets contain metabisulfite which may cause hypersensitivity; caution in patients dependent on opiates, since this substitution may result in acute opiate-withdrawal symptoms; caution in severe renal or hepatic dysfunction |
| Drug Name | Oxycodone and aspirin (Percodan) |
| Description | Drug combination indicated for relief of moderately severe to severe pain. |
| Adult Dose | 1-2 tab or cap PO q4-6h prn |
| Pediatric Dose | 0.05-0.15 mg/kg/dose oxycodone PO q4-6h prn; not to exceed 5 mg/dose of oxycodone |
| Contraindications | Documented hypersensitivity; liver damage; hypoprothrombinemia; vitamin K deficiency; bleeding disorders; asthma; because of association of aspirin with Reye syndrome, do not use in children (<16 y) who have flu |
| Interactions | Phenothiazines may decrease analgesic effects; CNS depressants or tricyclic antidepressants may increase toxicity; may potentiate anticoagulant effects of warfarin |
| Pregnancy | D - Fetal risk shown in humans; use only if benefits outweigh risk to fetus
|
| Precautions | Duration of action may increase in elderly; be aware of total daily dose of acetaminophen patient is receiving; do not exceed 4,000 mg/24 h of acetaminophen; higher doses may cause liver toxicity |
Drug Category: Anxiolytics
Patients with painful injuries usually experience significant anxiety. Anxiolytics allow the clinician to administer a smaller analgesic dose to achieve the same effect.
| Drug Name | Lorazepam (Ativan) |
| Description | Sedative hypnotic in benzodiazepine class that has short onset of effect and relatively long half-life. By increasing action of GABA, a major inhibitory neurotransmitter, may depress all levels of CNS, including limbic and reticular formation. Excellent for patients who require sedation for longer than 24 h. Monitor BP after administering and adjust as necessary. |
| Adult Dose | 1-10 mg/d PO/IV/IM divided bid/tid; not to exceed 4 mg/dose |
| Pediatric Dose | 0.05-0.1 mg/kg IV slowly over 2-5 min; may repeat a dose of 0.05 mg/kg IV slowly; not to exceed 4 mg/dose |
| Contraindications | Documented hypersensitivity; preexisting CNS depression; hypotension; narrow-angle glaucoma |
| Interactions | Toxicity of benzodiazepines in CNS increases when used concurrently with alcohol, phenothiazines, barbiturates, and MAOIs |
| Pregnancy | D - Fetal risk shown in humans; use only if benefits outweigh risk to fetus
|
| Precautions | Caution in renal or hepatic impairment, myasthenia gravis, organic brain syndrome, or Parkinson disease |
Drug Category: Nonsteroidal anti-inflammatory agents (NSAIDs)
These agents are used most commonly for the relief of mild to moderately severe pain. Although the effects of NSAIDs in the treatment of pain tend to be patient specific, ibuprofen is usually the DOC for initial therapy. Other options include flurbiprofen, ketoprofen, and naproxen.
| Drug Name | Ibuprofen (Ibuprin, Advil, Motrin) |
| Description | DOC for treatment of mild to moderately severe pain, if no contraindications. Inhibits inflammatory reactions and pain, probably by decreasing activity of enzyme cyclooxygenase, inhibiting prostaglandin synthesis. |
| Adult Dose | 200-400 mg PO q4-6h prn; not to exceed 3.2 g/d |
| Pediatric Dose | <6 months: Not established 6 months to 12 years: 20-40 mg/kg/d PO divided tid/qid >12 years: Administer as in adults |
| Contraindications | Documented hypersensitivity; peptic ulcer disease; recent GI bleeding or perforation; renal insufficiency; high risk of bleeding |
| Interactions | Coadministration with aspirin increases risk of inducing serious NSAID-related adverse effects; probenecid may increase concentrations and, possibly, toxicity; may decrease effects of hydralazine, captopril, and beta-blockers; may decrease diuretic effects of furosemide and thiazides; may increase PT in patients taking anticoagulants (monitor PT carefully and instruct patients to watch for signs of bleeding); may increase risk of methotrexate toxicity; may increase phenytoin levels |
| Pregnancy | B - Fetal risk not confirmed in studies in humans but has been shown in some studies in animals D - Fetal risk shown in humans; use only if benefits outweigh risk to fetus
|
| Precautions | Caution in CHF, hypertension, and decreased renal or hepatic function; caution in anticoagulation abnormalities or during anticoagulant therapy (monitor PT carefully and instruct patients to watch for signs of bleeding) |
| Drug Name | Ketoprofen (Oruvail, Orudis, Actron) |
| Description | Used for relief of mild to moderately severe pain and inflammation. Administer small dosages initially to patients with a small body size, the elderly, and those with renal or liver disease. Doses higher than 75 mg do not increase its therapeutic effects. Administer high doses with caution and closely observe the patient for response. |
| Adult Dose | 25-50 mg PO q6-8h prn; not to exceed 300 mg/d |
| Pediatric Dose | <3 months: Not established 3 months to 12 years: 0.1–1 mg/kg PO q6-8h >12 years: Administer as in adults |
| Contraindications | Documented hypersensitivity |
| Interactions | Coadministration with aspirin increases risk of inducing serious NSAID-related adverse effects; probenecid may increase concentrations and, possibly, toxicity; may decrease effects of hydralazine, captopril, and beta-blockers; may decrease diuretic effects of furosemide and thiazides; may increase PT in patients taking anticoagulants (monitor PT carefully and instruct patients to watch for signs of bleeding); may increase risk of methotrexate toxicity; may increase phenytoin levels |
| Pregnancy | B - Fetal risk not confirmed in studies in humans but has been shown in some studies in animals D - Fetal risk shown in humans; use only if benefits outweigh risk to fetus
|
| Precautions | Caution in CHF, hypertension, and decreased renal or hepatic function; caution in anticoagulation abnormalities or during anticoagulant therapy (monitor PT carefully and instruct patient to monitor for signs of bleeding) |
| Drug Name | Flurbiprofen (Ansaid, Ocufen) |
| Description | Has analgesic, antipyretic, and anti-inflammatory effects. May inhibit cyclooxygenase enzyme, inhibiting prostaglandin biosynthesis. |
| Adult Dose | 200-300 mg/d PO divided bid/qid |
| Pediatric Dose | Not established |
| Contraindications | Documented hypersensitivity |
| Interactions | Coadministration with aspirin increases risk of inducing serious NSAID-related adverse effects; probenecid may increase concentrations and, possibly, toxicity; may decrease effects of hydralazine, captopril, and beta-blockers; may decrease diuretic effects of furosemide and thiazides; may increase PT in patients taking anticoagulants (monitor PT carefully and instruct patients to watch for signs of bleeding); may increase risk of methotrexate toxicity; may increase phenytoin levels |
| Pregnancy | C - Fetal risk revealed in studies in animals but not established or not studied in humans; may use if benefits outweigh risk to fetus
|
| Precautions | Acute renal insufficiency, interstitial nephritis, hyperkalemia, hyponatremia, and renal papillary necrosis may occur; patients with preexisting renal disease or compromised renal perfusion risk acute renal failure; leukopenia occurs rarely, is transient, and usually returns to normal during therapy; persistent leukopenia, granulocytopenia, or thrombocytopenia warrants further evaluation and may require discontinuation of drug |
| Drug Name | Naproxen (Anaprox, Naprelan, Naprosyn) |
| Description | Used for relief of mild to moderately severe pain. Inhibits inflammatory reactions and pain by decreasing activity of enzyme cyclooxygenase, decreasing prostaglandin synthesis. |
| Adult Dose | 500 mg PO initial dose, followed by 250 mg q6-8h; not to exceed 1.25 g/d |
| Pediatric Dose | <2 years: Not established >2 years: 2.5 mg/kg/dose PO; not to exceed 10 mg/kg/d |
| Contraindications | Documented hypersensitivity; peptic ulcer disease; recent GI bleeding or perforation; renal insufficiency |
| Interactions | Coadministration with aspirin increases risk of inducing serious NSAID-related adverse effects; probenecid may increase concentrations and, possibly, toxicity; may decrease effects of hydralazine, captopril, and beta-blockers; may decrease diuretic effects of furosemide and thiazides; may increase PT in patients taking anticoagulants (monitor PT closely and instruct patients to watch for signs of bleeding); may increase risk of methotrexate toxicity; may increase phenytoin levels |
| Pregnancy | B - Fetal risk not confirmed in studies in humans but has been shown in some studies in animals D - Fetal risk shown in humans; use only if benefits outweigh risk to fetus
|
| Precautions | Acute renal insufficiency, interstitial nephritis, hyperkalemia, hyponatremia, and renal papillary necrosis may occur; patients with preexisting renal disease or compromised renal perfusion risk acute renal failure; leukopenia occurs rarely, is transient, and usually returns to normal during therapy; persistent leukopenia, granulocytopenia, or thrombocytopenia warrants further evaluation and may require discontinuation of drug |
Further Inpatient Care
- Vascular examination findings may be normal in the presence of significant popliteal artery injury. Most authors used to recommend mandatory arteriograms or operative exploration for all knee dislocations, but recent literature has questioned the need for this. Recent studies have shown good vascular assessment with the ankle-brachial index, Duplex scanning, or both. Briefly, the ankle-brachial index compares the Doppler pressure of an arm to a leg to screen for lower limb ischemia. This straightforward measurement is performed by recording the highest Doppler sound of the brachial pulse and comparing it to the highest Doppler sound of the posterior tibial or dorsalis pedis artery. The ankle Doppler pressure is then divided by the brachial Doppler pressure to calculate the index. Indexes less than 0.9 indicate an abnormal result.
- Time is of utmost concern, as vascular repair more than 8 hours after injury carries an amputation rate of greater than 80%. In contrast, operative vascular repair within 8 hours of injury yields a limb-salvage rate of 80%.
- The repair of coexistent popliteal vein injury is controversial. Fasciotomy is recommended after vascular repair, as severe swelling and development of compartment syndrome are common in the postoperative phase.
- Operative repair of nerve injury remains controversial, as a poor prognosis is common with both operative and nonoperative care.
- Operative ligamentous repair is recommended by most authors, as functional results are better than those of nonoperative care.
Transfer
- Patients considered for transfer should have undergone emergency reduction of the knee dislocation. Since time is crucial in salvaging the limb after a vascular injury, transfer should be initiated only if vascular consultation and/or evaluation are not available at the transferring institution or if an arteriogram has been performed and results are normal.
Complications
- Popliteal artery injury
- Popliteal vein injury
- Peroneal nerve injury
- Ligamentous injury
- Compartment syndrome
Prognosis
- When treated expeditiously and appropriately, 60-70% of patients will have a painless, stable knee. Of the remaining patients, one half will eventually have reasonable function, while the other half will have a chronically unstable and painful knee.
Patient Education
Medical/Legal Pitfalls
- Failure to perform reduction expeditiously
- Failure to consider an associated vascular injury
- Failure to recognize a spontaneously reduced dislocation
Special Concerns
- Knee dislocation is a serious limb-threatening injury that needs to be recognized and treated expeditiously. The possibility of vascular injury must be pursued actively, as it contributes significantly to the morbidity associated with this disorder.
| Media file 5:
Lateral knee dislocation after reduction (same patient as in Image 2). |
 | View Full Size Image | |
Media type: Photo
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Dislocations, Knee excerpt Article Last Updated: Nov 29, 2007
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