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Author: Lynnus F Peng, MD, Assistant Clinical Professor, Department of Anesthesia, University of California at Irvine; Chairman of Anesthesia, Department of Surgery, St Jude Medical Center at Fullerton

Lynnus F Peng is a member of the following medical societies: Alpha Omega Alpha and American Society of Anesthesiologists

Coauthor(s): A Antoine Kazzi, MD, Chief of Service, Department of Emergency Medicine, Medical Director of the Emergency Unit, American University of Beirut; Willard Peng, BA, BS, MS, Doctor of Dental Surgery Candidate, Department of Oral Medicine, University of Southern California; Rebecca Cheng, University of California at San Diego

Editors: Michael Glick, DMD, Professor and Acting Chair, Department of Diagnostic Sciences, New Jersey Dental School, University of Medicine and Dentistry of New Jersey; Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine; Mark W Fourre, MD, Program Director, Department of Emergency Medicine, Maine Medical Center; Associate Clinical Professor, Department of Surgery, University of Vermont School of Medicine; John Halamka, MD, Chief Information Officer, CareGroup Healthcare System, Assistant Professor of Medicine, Department of Emergency Medicine, Beth Israel Deaconess Medical Center; Assistant Professor of Medicine, Harvard Medical School; Barry E Brenner, MD, PhD, FACEP, Program Director, Department of Emergency Medicine, University Hospitals, Case Medical Center

Author and Editor Disclosure

Synonyms and related keywords: tooth loss, tooth avulsion, tooth reimplantation, knocked-out tooth, tooth trauma, missing tooth, losing a tooth, displaced tooth, tooth displacement, periodontal disease, alveolar socket, hypoxia, necrosis of pulp, tooth reimplantation, periodontal ligament, root canal, alveolar bone, dentoalveolar ankylosis, Panorex, maxillary fractures, mandibular fractures, Hanks solution, Save-A-Tooth, zinc oxide preparation, Coe-Pak, root canal, infected necrotic tooth pulp

Background

Losing a tooth can be physically and emotionally trying, as the resulting empty site is not aesthetically pleasing and is difficult to fill and difficult to replace. Long-term sequelae include shifting of remaining teeth with resulting misalignment and periodontal disease.

As early as 400 BCE, Hippocrates suggested that displaced teeth should be replaced and fastened to adjacent teeth with wire. Modern emergency departments focus on reimplanting teeth as soon as possible, minimizing periodontal damage, and preventing infection of the pulp tissue.

Pathophysiology

The usual cause is a directed force sufficient to overcome the bond between the affected tooth and the periodontal ligament within the cradling alveolar socket. Avulsion results in hypoxia and eventual necrosis of the pulp. The primary goal of rapid reimplantation is to preserve the periodontal ligament, not the tooth. The avulsed tooth inevitably requires a root canal; however, if the periodontal ligament survives, the degree and timeliness of root resorption is improved and ankylosis is decreased.

Frequency

United States

The prevalence of avulsion from traumatic injury of primary dentition is 7-13%. In permanent teeth, the prevalence is 1-16%.

International

A study conducted in Sweden showed approximately 7% of all physical injuries involved the oral cavity. In patients aged 0-19 years, 9% of all injuries involved the oral cavity. In the same study, more than 50% of physical trauma in child abuse cases occurred in the head and neck region.

Facial injuries are common during war. During the Korean War, maxillofacial injuries numbered 3,000.

Mortality/Morbidity

Trauma to the teeth is not life threatening; however, associated maxillofacial injuries and fractures can compromise the airway. Morbidity to the teeth may be individualized to primary or permanent teeth. Teeth with avulsion actually continue deteriorating, even at the 36-month follow-up appointment.

  • Primary teeth
    • Failure to continue eruption
    • Color changes
    • Infection
    • Abscess
    • Loss of space in the dental arch
    • Ankylosis
    • Injury to the permanent teeth
    • Abnormal exfoliation
  • Permanent teeth
    • Color changes
    • Infection
    • Abscess
    • Loss of space in the dental arch
    • Ankylosis
    • Resorption of root structure
    • Abnormal root development

Sex

The male-to-female ratio is 2-3:1.

Age

The average age of injury varies. In youths, falls and sporting activities account for most injuries. In later teenaged years, motor vehicle collisions (MVCs) and assaults account for most injuries.



History

  • Patient's age: Anterior primary teeth are usually present until age 6-7 years.
  • Mechanism of injury: Rule out concomitant injuries.
  • Location of the tooth when recovered: This helps assess contamination.
  • Time out of socket: If the tooth was absent for less than 20 minutes, the prognosis is better. All periodontal ligament cells die if the tooth is out of the socket longer than 60 minutes.
  • Storage media: Determine if the tooth was stored dry or in solution.
  • Transport method: Determine how the tooth was carried. Holding it by the root is typically worse.
  • Primary or permanent tooth: Do not replace primary teeth, because loss of these teeth early does not hinder development of succedaneous teeth. When loss of a primary tooth is early, eruption of permanent successors may be delayed.
    • If replaced, primary teeth have a high likelihood of fusing to underlying alveolar bone, which causes dentoalveolar ankylosis and can result in facial deformities.
    • Histologically, dentoalveolar ankylosis is characterized by direct contact between bone and cementum without separation by the periodontal ligament.

Physical

  • Inspection
    • Evaluate the surrounding soft tissue area for laceration, discoloration, ecchymosis, and embedded foreign bodies (eg, chipped teeth).
    • Evaluate teeth for fractures, chips, and other deformities. Embedded tooth fragments may lead to chronic infection or fibrosis.
  • Palpation
    • Determine if the tooth or if an entire segment is mobile.
    • If possible, have patients bite down to further localize the suspected area.
  • Percussion and sensitivity
    • Percuss with a tongue blade to evaluate overall sensitivity.
    • Evaluate the patient's sensitivity to air and hot and cold solutions.
  • Missing tooth: If the tooth is not found, consider complete intrusion of the tooth into underlying alveolar bone.

Causes

  • Unknown (17%)
  • Altercations (17%)
  • Contact sports (15.9%)
  • Motor vehicle collision (10.8%)
  • Motorcycle accident (10.4%)
  • Ice hockey (2.3%)



Dental, Displaced Tooth
Dental, Fractured Tooth


Imaging Studies

  • Four films (maxillary anterior, 3 periapical from various angles) are recommended to evaluate dental injury, displacement, or possible complete intrusion.
    • Because these specialized films are often not available in the emergency department, a limited facial series and a Panorex may be used to evaluate foreign bodies, displacement, and maxillary and mandibular fractures.
    • A Panorex may be used to assess mandibular fracture.



Prehospital Care

  • Do not touch the root or clean the tooth. Handle the tooth by the crown only. Attempt reimplantation in the field. If unable to reimplant, use one of the following carrier media (in order of preference):
    • Hanks solution (Save-A-Tooth, Phoenix-Lazerus, Inc, Pottstown, PA): This pH-preserving fluid is best used with a trauma-reducing suspension apparatus.
    • Milk: Shown to maintain vitality of periodontal ligament cells for 3 hours, milk is relatively bacteria-free with pH and osmolarity compatible with vital cells.
    • Saline: Saline is isotonic and sterile.
    • Saliva: Saliva keeps the tooth moist; however, it is not ideal because of incompatible osmolarity, pH, and presence of bacteria.
    • Water: This is the least desirable transport medium because it results in hypotonic rapid cell lysis.

Emergency Department Care

  • Tooth preparation: Handle the tooth by the crown and rinse with normal saline.
    • If extraoral time is less than 20 minutes, gently rinse off the root and reimplant as soon as possible. If the pulp is open, use a bathing solution (doxycycline 1 mg in 20 mL isotonic sodium chloride solution) for 5 minutes to inhibit the amount of pathogens reaching the pulp lumen and enhance vascularization. Consult a dentist prior to use.
    • If extraoral time is longer 60 minutes, soak the tooth in citric acid and fluoride to make the root as resistant to resorption as possible. Consult a dentist.
  • Socket preparation
    • Leave the socket alone as much as possible.
    • If extraoral time is 20-60 minutes, soak in Hanks solution for 30 minutes before attempting reimplantation.
    • Perform light aspiration if a blood clot remains.
    • Gently irrigate for foreign bodies.
  • Tooth stabilization: If untrained in placing arch bars for tooth stabilization, use a zinc oxide preparation (Coe-Pak) for rapid support and stabilization. Mold the zinc oxide mixture over the gingival area and between teeth to provide support.
  • Provide adequate pain management and tetanus vaccination; ensure follow-up care.

Consultations

  • Consult a dental or oral maxillofacial surgeon for splinting and further evaluation.



The goals of therapy are to relieve pain with analgesics and to prevent complications with antibiotics.

Drug Category: Antibiotics

Therapy must cover all likely pathogens in the context of the clinical setting.

Drug NamePenicillin VK (Veetids, Beepen-VK, Betapen-VK)
DescriptionInhibits biosynthesis of cell wall mucopeptide and is effective during active multiplication. Inadequate concentrations may produce only bacteriostatic effects.
Adult Dose250-500 mg PO q6h
Pediatric Dose50 mg/kg/d PO divided qid
ContraindicationsDocumented hypersensitivity
InteractionsProbenecid may increase effectiveness by decreasing clearance; tetracyclines are bacteriostatic, causing a decrease in the effectiveness of penicillins when administered concurrently
PregnancyC - Fetal risk revealed in studies in animals but not established or not studied in humans; may use if benefits outweigh risk to fetus
PrecautionsCaution in renal impairment

Drug NameErythromycin (EES, E-Mycin, Ery-Tab)
DescriptionAn alternative for patients allergic to penicillin. Advise patients to take with food/milk if GI upset noted.
Inhibits RNA-dependent protein synthesis, possibly by stimulating dissociation of peptidyl tRNA from ribosomes. This inhibits bacterial growth.
Adult Dose200-500 mg PO q6h
Pediatric Dose30-50 mg/kg/d PO divided qid
ContraindicationsDocumented hypersensitivity; hepatic impairment
InteractionsCoadministration may increase toxicity of theophylline, digoxin, carbamazepine, and cyclosporine; may potentiate anticoagulant effects of warfarin; coadministration with lovastatin and simvastatin increases risk of rhabdomyolysis
PregnancyB - Fetal risk not confirmed in studies in humans but has been shown in some studies in animals
PrecautionsCaution in liver disease; estolate formulation may cause cholestatic jaundice; GI adverse effects are common (give doses pc); discontinue use if nausea, vomiting, malaise, abdominal colic, or fever occurs

Drug NameAmoxicillin (Amoxil, Polymox, Trimox)
DescriptionInterferes with synthesis of cell wall mucopeptide during active multiplication, resulting in a bactericidal activity against susceptible bacteria.
Adult Dose250-500 mg PO q8h
Pediatric Dose20-50 mg/kg/d PO divided q8h
ContraindicationsDocumented hypersensitivity
InteractionsReduces efficacy of oral contraceptives
PregnancyB - Fetal risk not confirmed in studies in humans but has been shown in some studies in animals
PrecautionsAdjust dose in renal impairment

Drug Category: Analgesics

Pain control is essential to quality patient care. Analgesics ensure patient comfort, promote pulmonary toilet, and have sedating properties that benefit patients who have sustained trauma.

Drug NameOxycodone and acetaminophen (Percocet)
DescriptionDrug combination indicated for relief of moderate to severe pain. DOC for aspirin-hypersensitive patients.
Adult Dose1-2 tab or cap PO q4-6h prn
Pediatric Dose0.05-0.15 mg/kg/dose oxycodone PO; not to exceed 5 mg/dose of oxycodone q4-6h prn
ContraindicationsDocumented hypersensitivity
InteractionsPhenothiazines may decrease analgesic effects of this medication; toxicity increases with coadministration of either CNS depressants or tricyclic antidepressants
PregnancyC - Fetal risk revealed in studies in animals but not established or not studied in humans; may use if benefits outweigh risk to fetus
PrecautionsDuration of action may increase in elderly persons; be aware of total daily dose of acetaminophen patient is receiving; do not exceed 4,000 mg/d of acetaminophen; higher doses may cause liver toxicity

Drug NameHydrocodone bitartrate and acetaminophen (Vicodin ES)
DescriptionDrug combination indicated for relieving moderate to severe pain.
Adult Dose1-2 tab or cap PO q4-6h prn
Pediatric Dose<12 years: 10-15 mg/kg/dose acetaminophen PO q4-6h prn; not to exceed 2.6 g/d acetaminophen
>12 years: 750 mg acetaminophen PO q4h; single dose should not exceed 10 mg of hydrocodone bitartrate; not to exceed 5 doses in 24 h
ContraindicationsDocumented hypersensitivity; high-altitude cerebral edema (HACE) or elevated intracranial pressure (ICP)
InteractionsCoadministration with phenothiazines may decrease analgesic effects; toxicity increases with CNS depressants or tricyclic antidepressants
PregnancyC - Fetal risk revealed in studies in animals but not established or not studied in humans; may use if benefits outweigh risk to fetus
PrecautionsTabs contain metabisulfite, which may cause hypersensitivity; caution in patients dependent on opiates because this substitution may result in acute opiate-withdrawal symptoms; caution in severe renal or hepatic dysfunction

Drug NameAcetaminophen and codeine (Tylenol #3)
DescriptionDrug combination indicated for treating mild to moderate pain.
Adult DoseBased on codeine content: 30-60 mg/dose PO q4-6h or 1-2 tab q4h; not to exceed 12 tab/d
Pediatric Dose0.5-1 mg/kg/dose based on codeine PO q4-6h; 10-15 mg/kg/dose based on acetaminophen content; not to exceed 2.6 g/d of acetaminophen
ContraindicationsDocumented hypersensitivity
InteractionsToxicity increases with CNS depressants or tricyclic antidepressants
PregnancyC - Fetal risk revealed in studies in animals but not established or not studied in humans; may use if benefits outweigh risk to fetus
PrecautionsCaution in patients dependent on opiates because this substitution may result in acute opiate-withdrawal symptoms; caution in severe renal or hepatic dysfunction

Drug NameAcetaminophen (Tylenol, Panadol, Aspirin-free Anacin)
DescriptionDOC for treating pain in patients with documented hypersensitivity to aspirin or NSAIDs, with upper GI disease, or who take oral anticoagulants.
Adult Dose325-650 mg PO q4-6h or 1,000 mg tid/qid; not to exceed 4 g/d
Pediatric Dose<12 years: 10-15 mg/kg/dose PO q4-6h prn; not to exceed 2.6 g/d
>12 years: 325-650 mg PO q4h; not to exceed 5 doses/d
ContraindicationsDocumented hypersensitivity; known G-6-PD deficiency
InteractionsRifampin can reduce analgesic effects of acetaminophen; coadministration with barbiturates, carbamazepine, hydantoins, and isoniazid may increase hepatotoxicity
PregnancyB - Fetal risk not confirmed in studies in humans but has been shown in some studies in animals
PrecautionsHepatotoxicity possible in people with chronic alcoholism following various dose levels; severe or recurrent pain or high or continued fever may indicate a serious illness; acetaminophen is contained in many OTC products and combined use with these products may result in cumulative acetaminophen doses exceeding recommended maximum dose



Further Outpatient Care

  • Advise patients to follow up with a dentist within 24 hours. Document arrangements for follow-up care.
  • Advise patients to avoid eating solid foods to prevent loss of stabilizing dressing.
  • Finding the missing tooth is critical because successful reimplantations have occurred even the tooth being in dry storage for 1 week.

Complications

  • Loss of tooth
  • Cosmetic deformity
  • Infection

Prognosis

  • Immature permanent teeth have a higher chance of survival than older permanent teeth.
  • Root canal is necessary when necrotic tooth pulp becomes infected. Infection can pass from the pulp through the dentin tubules and stimulate an inflammatory response, resulting in inflammatory root resorption.
  • The chance of a successful reimplantation is dependent upon the amount of time the tooth has been out of the socket. Education of patients toward self-reimplantation may help to decrease the out-of-socket time.

Patient Education



Medical/Legal Pitfalls

  • Delaying reimplantation
  • Failure to properly handle and transport tooth
  • Attempting to reimplant primary tooth
  • Failure to provide tetanus prophylaxis
  • Failure to rule out aspiration of tooth chips when unable to recover tooth in the field
  • Failure to properly examine surrounding traumatized tissue for tooth chips
  • Failure to recognize domestic or child abuse
  • Failure to fully evaluate the temporomandibular joint, maxilla, mandible, and associated head or neck injuries
  • Failure to recognize possible airway compromise
  • Failure to warn patients that any trauma to teeth may disrupt the neurovascular supply and lead to long-term pulp necrosis or root resorption



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Dental, Avulsed Tooth excerpt

Article Last Updated: Nov 8, 2007