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Follow-Up

Follow-up

Deterrence/Prevention:

  • Scurvy can be prevented by consuming fresh fruit and vegetables. As little as 6-10 mg of vitamin C a day is sufficient to maintain body stores of more than 350 mg.

Complications:

  • Lethargy, fatigue, and hemorrhagic manifestations of impaired collagen synthesis affecting oral, ophthalmic, musculoskeletal, cardiac, and gastrointestinal structures and functions may occur.
  • Cerebral hemorrhage or hemopericardium are potential complications that may lead to death.

Patient Education:

  • Patients and their families should be educated about proper nutrition.
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Bibliography

  1. Abernethy DR, Arnold GJ, Azarnoff D: Mosby Drug Consult. St. Louis, Mo: Mosby; 2005.
  2. Carinci F, Pezzetti F, Spina AM, et al: Effect of Vitamin C on pre-osteoblast gene expression. Arch Oral Biol 2005 May; 50(5): 481-96 [Medline].
  3. Emadi-Konjin P, Verjee Z, Levin AV, Adeli K: Measurement of intracellular vitamin C levels in human lymphocytes by reverse phase high performance liquid chromatography (HPLC). Clin Biochem 2005 May; 38(5): 450-6[Medline].
  4. Fain O: Musculoskeletal manifestations of scurvy. Joint Bone Spine 2005 Mar; 72(2): 124-8[Medline].
  5. Formon J: Nutrition of Normal Infants. Chicago, Ill: Mosby-Year Book; 1993: 22, 360-5.
  6. Garg K, Draganescu JM, Albornoz MA: Puzzles in practice. A rash imposition from a lifestyle omission. Vitamin C deficiency. Postgrad Med 1998 Nov; 104(5): 183-4[Medline].
  7. Ghorbani AJ, Eichler C: Scurvy. J Am Acad Dermatol 1994 May; 30(5 Pt 2): 881-3[Medline].
  8. Grainger RG, Allison D, Adam A: Grainger & Allison's Diagnostic Radiology: A Textbook of Medical Imaging. 4th ed. New York, NY: Churchill Livingstone; 2001: 1941-3.
  9. Hasan L, Vogeli P, Stoll P, et al: Intragenic deletion in the gene encoding L-gulonolactone oxidase causes vitamin C deficiency in pigs. Mamm Genome 2004 Apr; 15(4): 323-33[Medline].
  10. Hatuel H, Buffet M, Mateus C, et al: Scurvy in liver transplant patients. J Am Acad Dermatol 2006 Jul; 55(1): 154-6[Medline].
  11. Hirschmann JV, Raugi GJ: Adult scurvy. J Am Acad Dermatol 1999 Dec; 41(6): 895-906; quiz 907-10[Medline].
  12. McKenna KE, Dawson JF: Scurvy occurring in a teenager. Clin Exp Dermatol 1993 Jan; 18(1): 75-7[Medline].
  13. Olmedo JM, Yiannias JA, Windgassen EB, Gornet MK: Scurvy: a disease almost forgotten. Int J Dermatol 2006 Aug; 45(8): 909-13[Medline].
  14. Onorato J, Lynfield Y: Scurvy. Cutis 1992 May; 49(5): 321-2[Medline].
  15. Pimentel L: Scurvy: historical review and current diagnostic approach. Am J Emerg Med 2003 Jul; 21(4): 328-32[Medline].
  16. Sarkany RPE, Breathnach SM, Seymour CA: Vitamin C deficiency. Rook's Textbook of Dermatology 2004; 57: 94-95.
  17. Schnitzler CM, Schnaid E, MacPhail AP, et al: Ascorbic acid deficiency, iron overload and alcohol abuse underlie the severe osteoporosis in black African patients with hip fractures--a bone histomorphometric study. Calcif Tissue Int 2005 Feb; 76(2): 79-89[Medline].
  18. Yalcin A, Ural AU, Beyan C, et al: Scurvy presenting with cutaneous and articular signs and decrease in red and white blood cells. Int J Dermatol 1996 Dec; 35(12): 879-81[Medline].

Scurvy excerpt

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Synonyms And Related Keywords

incapacitating agent; opioid; fentanyl; carfentanil; alfentanil; sufentanil; benzodiazepine; diazepam; chemical warfare agents; chemical, biological, radiological, nuclear, and explosive threat agents; chemical weapons; benzodiazepine toxicity; opioid toxicity.

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Author Information and Disclosures

Author: Anne Laumann, MBChB, MRCP(UK), Associate Professor, Department of Dermatology, Northwestern University

Coauthor(s): Tarita Thomas, PhD, MBA, Medical Scientist Training Program, Feinberg School of Medicine, Northwestern University; Janet J Wong, MD, Consulting Dermatologist, Department of Dermatology, University of Connecticut

Anne Laumann, MBChB, MRCP(UK), is a member of the following medical societies: American Academy of Dermatology, Chicago Medical Society, Illinois State Medical Society, Society for Investigative Dermatology, and Women's Dermatological Society

Editor Information

Editor(s): Kathryn Schwarzenberger, MD, Associate Professor, Departments of Dermatology and Medicine, Medical University of South Carolina; Michael J Wells, MD, Associate Professor, Department of Dermatology, Texas Tech University Health Sciences Center; Van Perry, MD, Assistant Professor, Department of Medicine, Division of Dermatology, University of Texas Health Science Center; Catherine Quirk, MD, Clinical Assistant Professor, Department of Dermatology, Brown University; and Dirk M Elston, MD, Director, Department of Dermatology, Geisinger Medical Center

 
 
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