You are in: eMedicine Specialties > Dermatology > REACTIVE AND INFLAMMATORY DERMATOSES Tattoo ReactionsArticle Last Updated: Feb 1, 2007AUTHOR AND EDITOR INFORMATIONSection 1 of 8
  Author: Elizabeth L Tanzi, MD, Co-Director, Laser Surgery, Washington Institute of Dermatologic Laser Surgery Elizabeth L Tanzi is a member of the following medical societies: American Academy of Dermatology, American Medical Association, American Society for Dermatologic Surgery, and American Society for Laser Medicine and Surgery Coauthor(s): Elias Michael, MD, Director of Consult Service, Department of Dermatology, Assistant Clinical Professor, St Luke's/Roosevelt Hospital Center, Columbia University Editors: John D Wilkinson, MD, MBBS, MRCS, FRCP, Chairman, Clinical Director, Department of Dermatology, Amersham Hospital and High Wycombe Hospital, UK; Richard P Vinson, MD, Assistant Clinical Professor, Department of Dermatology, Texas Tech University School of Medicine; Consulting Staff, Mountain View Dermatology, PA; Paul Krusinski, MD, Director of Dermatology, Professor, Department of Internal Medicine, Fletcher Allen Health Care, University of Vermont; Catherine Quirk, MD, Clinical Assistant Professor, Department of Dermatology, Brown University; Dirk M Elston, MD, Director, Department of Dermatology, Geisinger Medical Center Author and Editor Disclosure Synonyms and related keywords: iatrogenic tattoos, traumatic tattoos, decorative tattoos, tattoo removal, acute inflammatory reactions, eczematous hypersensitivity reactions, photo-aggravated reactions, granulomatous reactions, lichenoid hypersensitivity reactions, lichenoid reactions, pseudolymphomatous reaction INTRODUCTIONSection 2 of 8
  The term tattoo describes the deliberate placement of permanent colors into the skin or the accidental entry of pigmented material. Accidental tattooing may occur after abrasion injuries. Rare iatrogenic tattoos have developed after the use of Monsel solution or ferric chloride for coagulation purposes. Traumatic tattoos are not uncommon; however, decorative tattoos are the most common form. Decorative tattooing has been practiced for thousands of years. Tattooing remains a common custom in various countries and cultures. It gained popularity in many western countries throughout the 1990s. In the past, decorative tattoos were primarily seen in men, especially in groups such as sailors and members of the armed forces; however, they are increasingly observed in young professionals of both sexes. The components of many tattoo pigments have been identified, although new formulations continue to be created (see Tattoo Pigments). Complications resulting from decorative tattoos are relatively rare considering the popularity of tattooing; however, the introduction of foreign substances into the skin can result in a toxic or immunologic response. In addition to the transmission of infectious disease, reactions to tattoo pigments have also been described. These reactions include acute inflammatory reaction; allergic hypersensitivity; and granulomatous, lichenoid, and pseudolymphomatous types of histopathologic reactions. Localization of skin disease in tattoos has also been documented. Tattoo removal may be accomplished by a variety of methods and may be initiated whether the tattoo is responsible for an adverse reaction in the skin or for significant feelings of regret. TRANSMISSION OF INFECTIONSection 3 of 8
Tattoos are executed by professional tattoo artists using an electric needle to introduce particles of pigment into the dermis. The amateur tattoo artist may use any pointed object to place particles of India ink. Although significant infection secondary to tattoos is currently unusual, infection may be introduced into the skin during the breach of the epidermal barrier. Pyogenic infection resulting in erysipelas and gangrene were a problem in the past, but localized skin infection secondary to gram-positive bacteria is seldom serious today. Transmission of tuberculosis, syphilis, leprosy, hepatitis, and HIV has also been recorded. By using a previously used and infected tattoo needle, inoculation with vaccinia and human papilloma virus has been responsible for localized disease by passing the disease from one person to the next. TYPES OF REACTIONSSection 4 of 8
Acute inflammatory reactions Acute inflammatory reactions are associated with physical tissue injury and the injection of pigment dyes or metals into the skin. This reaction usually recedes without consequence within 2-3 weeks and is an expected adverse effect of the tattooing process. Eczematous hypersensitivity reactions Once acute inflammatory changes have resolved, the most frequent reaction observed with tattoos is an allergic sensitivity to one of its pigments. Individuals may manifest sensitivity to a particular pigment in several ways. Histopathologic evaluation of involved skin may reveal a spongiotic, granulomatous, or lichenoid type of tattoo reaction. Most often, hypersensitivity reactions to a tattoo pigment are contact dermatitis and photoallergic dermatitis. These conditions may manifest clinically as localized eczematous eruptions or, rarely, as an exfoliative dermatitis. Histopathologic findings include acanthosis, spongiosis, and a lymphocytic perivascular infiltrate. Allergic reactions to red tattoo pigments are the most common and may be caused by a variety of pigments, especially mercury sulfide (cinnabar). Patch testing may be positive for mercuric chloride but is not reliable for cinnabar. Alternative red dyes have been developed because of the problems associated with red tattoo pigment containing mercury; however, red tattoo reactions continue to be reported. Organic vegetable dyes are used more often than red pigments containing mercury and have been associated with eczematous reactions and negative patch test results. Because organic dyes are insoluble, little penetration into the epidermis occurs; therefore, a negative patch test result occurs. Allergic reactions may occur when organic dyes are injected into the dermis during tattoo placement. Photo-aggravated reactions Photo-aggravated reactions are most commonly caused by yellow (cadmium sulfide) tattoo pigment. Edema and erythema may develop upon exposure to sunlight. Although the mechanism is not clear, cadmium sulfide is the light-sensitive material used in photoelectric cells; therefore, the reaction is believed to be phototoxic. Red tattoos have been associated with photo-aggravated tattoo reactions less frequently than yellow tattoos, and most likely, these reactions are related to the trace amounts of cadmium added to brighten the red pigment. In contrast to hypersensitivity reactions to red tattoos, reactions to pigments used to create green, blue, and black tattoos are much less common. Chromium in green tattoo pigment is associated with localized eczematous reactions at the site of the pigment, eczema of the hands, and generalized eczematous reactions. Patients may be sensitized primarily by exposure to cement. Patch testing to 0.5% potassium dichromate is often positive. Blue tattoos that contain cobalt have been linked to localized hypersensitivity reactions and (rarely) spontaneous development of uveitis. Allergic reactions to black tattoo pigment are very rare, with fewer than 5 cases reported. Presumably, these patients were sensitive to carbon. Granulomatous reactions Granulomatous reactions may take 2 forms. Foreign body reaction to pigment can produce numerous pigment-filled giant cells. This reaction may be viewed as the counterpart to an irritant contact dermatitis. An immunologic granulomatous reaction is characterized by aggregates of epithelioid cells, a ring of lymphocytes, and a few giant cells. An immunologic granulomatous reaction may be indistinguishable from tattoo involvement seen as a Köbner response in sarcoidosis; therefore, further investigation, such as a complete review of systems and possible chest radiography, may be warranted to exclude systemic disease. Most commonly, mercury (red pigment) is associated with a granulomatous tattoo reaction; however, several reactions involving chromium (green pigment) and cobalt (blue pigment) have also been reported. In contrast to an eczematous hypersensitivity tattoo reaction in which patch test results may be positive, granulomatous tattoo reactions are most likely associated with negative patch test results. Manganese reportedly causes a granulomatous reaction in purple tattoos, but sufficient evidence is not available to establish manganese as the definitive etiologic agent. One patient was documented with a granuloma occurring in the violet areas of a tattoo shown to contain aluminum particles. Intradermal provocation testing to aluminum was positive in this patient. Granulomatous reactions have been reported in permanent eyeliner tattoos in several patients. Treatment is difficult because of the proximity to the lid margin. Lichenoid reactions Lichenoid hypersensitivity tattoo reactions are less common than eczematous reactions. Evidence exists that the lichenoid reaction is an expression of delayed hypersensitivity to a lymphocytic T-cell infiltrate, which may simulate the graft-versus-host response. Mercury (red pigment) is responsible for most lichenoid tattoo reactions. Clinically, warty papules or plaques typical of hyperkeratotic lichen planus are usually confined to the red portion of the tattoo, although a generalized lichen planus reaction developed in one patient with a history of a lichenoid tattoo reaction. This patient had occupational exposure to mercury. Histopathologically, the pattern of inflammation is consistent with that of lichen planus, including a bandlike infiltrate at the dermal-epidermal junction, liquefaction degeneration, hyaline bodies, and sawtooth rete ridges. Similar to granulomatous tattoo reactions, lichenoid reactions are associated with negative patch test results. Pseudolymphomatous reactions Delayed hypersensitivity to tattoo pigment may result in a pseudolymphomatous reaction. Lymphadenosis benigna cutis (pseudolymphoma) can develop after insect bites, after acupuncture, after antigen injection, after wearing of earrings, and in association with tattoo pigments. Tattoo-induced pseudolymphoma occurs primarily within red portions of the tattoo. This reaction is rarely induced by green or blue tattoos. Clinically, most reactions are characterized by flesh-to-plum or plum-red indurated nodules and plaques similar to cutaneous B-cell lymphoma. Be alert to this type of reaction to tattoo pigment to prevent an erroneous diagnosis of lymphoma. Pseudolymphoma may be distinguished from cutaneous lymphoma at histologic examination. Important features of a pseudolymphoma include germinal centers, a mixed cell infiltrate, prominent vasculature, and predominant involvement of the upper dermis compared with the lower dermis. Immunohistochemical studies may provide additional information that helps distinguish pseudolymphoma from malignant B-cell proliferation in the skin. Monotypic light-chain expression highly suggests malignant lymphoma, while the lymphocytes in pseudolymphoma primarily are polyclonal. LOCALIZATION OF DISEASE IN TATTOOSSection 5 of 8
Several cutaneous disorders show a predilection for tattooed skin. The eruption may represent the initial manifestation of the disease or the accentuation of an existing disorder in the area of the tattoo. Lichen planus, psoriasis, sarcoidosis, and lupus erythematosus have been associated with localization to the site of a tattoo. No color predilection is demonstrated in this localization response. Whether disease localized to the tattoo represents the Köbner phenomenon or results from a locus minoris resistentiae that predisposes the area to disease is unclear. Several patients with malignant melanoma occurring in a tattoo have been reported. Most of these documented cases include melanomas found in tattoo sites used for marking an irradiation field. The combination of India ink and irradiation may be responsible for carcinogenesis. The association may be coincidental in the patients without predisposing injury. TREATMENTSection 6 of 8
Tattoo removal may be required when complications develop. If an allergic reaction is noted, some cases resolve with topical or intralesional steroids, but permanent removal may be necessary. Most often, tattoo removal is sought for cosmetic reasons. Decorative tattoo removal can be accomplished by a variety of methods. Treatment modalities used in the past included cryosurgery, dermabrasion, carbon dioxide lasers, and cold steel surgical excision. These destructive methods replaced the tattoo with a permanent scar. In 1964, Goldman et al were the first to describe the removal of tattoos with the Q-switched ruby laser. These experiments were successful; however, the technique did not gain popularity until the 1990s. Laser tattoo removal often requires multiple treatments, and complete resolution of color may not be achieved in all cases. Lasers that can target specific pigment-containing structures in the skin have been developed using the theory of selective photothermolysis. The Q-switched ruby (694 nm), Q-switched Nd:YAG (1064 nm), Q-switched alexandrite (755 nm), Q-switched frequency-doubled Nd:YAG (532 nm), and the pigmented lesion pulsed dye (510 nm) lasers are used to remove various tattoo pigments. Before laser treatment, tattoo pigment is localized within perivascular fibroblasts, mast cells, and macrophages. After treatment with a Q-switched laser, rapid thermal expansion fragments the pigment-containing cells causing the pigment to become extracellular. The mechanism involved in removing tattoo pigment is not understood completely, but it most likely involves the release of ink particles into the extracellular space with subsequent lymphatic drainage and rephagocytosis of smaller residual ink particles. To a lesser extent, elimination of pigment by formation of scale-crust may be involved. Complications following laser treatment of tattoos have been documented. Laser treatment infrequently may cause a localized tattoo reaction to become generalized. Pigment released into the extracellular space after laser treatment may be viewed as foreign by the immune system, causing a hypersensitivity response. Laser-induced photochemical changes can occur in tattoo inks resulting in irreversible immediate darkening of the tattoo. Pigments, including red, brown, and white, used for cosmetic tattoos are at highest risk for this type of reaction. The darkening reaction may be masked by an immediate whitening action after laser treatment. The immediate whitening of the tattoo is likely caused by the formation of gas bubbles that intensely scatter light. A small test area is advised because this transient whitening reaction may obscure the darkening reaction. Most cosmetic tattoos contain iron (or titanium) oxide inks that, on QS laser irradiation, are reduced from ferric oxide to the ferrous oxide form; the latter being black and insoluble. Although this reaction pattern can usually be improved with continued pigment-specific QS laser treatments or vaporization with a carbon dioxide laser, the darkened color may be permanent. TATTOO PIGMENTSSection 7 of 8
The composition of tattoo pigment colors is as follows:
REFERENCESSection 8 of 8
Article Last Updated: Feb 1, 2007 |
