Excerpt from Follicular Infundibulum Tumor

Synonyms, Key Words, and Related Terms: tumor of the follicular infundibulum, infundibulomas, infundibulomatosis

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Background

Tumor of the follicular infundibulum is a rare benign adnexal tumor arising from the follicular infundibulum. The histopathology of the tumor is distinctive, which occurs as a platelike dermal nodule with multiple thin connections to the overlying epidermis (see Media Files 1-3). The tumor usually manifests as a single lesion, but an eruptive (multiple) form may occur.

Pathophysiology

A benign tumoral proliferation that arises from the follicular infundibulum. The external root sheath of the follicle has been shown to give rise to these tumors. A possible relation to sun exposure has been reported.

Frequency

International

Follicular infundibulum tumor is uncommon. Since the original report from Mehregan and Butler in 1961, only a few new cases have been reported. The overall relative frequency ranges from 3-10 cases per 100,000 specimens examined.

Mortality/Morbidity

The tumor is benign, although malignant transformation to a basal cell carcinoma was reported twice in a patient with multiple lesions.

Race

No racial predilection is known.

Sex

A slight female predominance is recognized.

Age

Most cases occur in patients older than 60 years.

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