Excerpt from Cheilitis Granulomatosa (Miescher-Melkersson-Rosenthal Syndrome)

Synonyms, Key Words, and Related Terms: granulomatous cheilitis, orofacial granulomatosis, Miescher cheilitis, Melkersson-Rosenthal syndrome, Rossolimo-Melkersson-Rosenthal syndrome, swelling of the lip, Crohn disease, Crohn's disease

Please click here to view the full topic text: Cheilitis Granulomatosa (Miescher-Melkersson-Rosenthal Syndrome)

Background

Granulomatous cheilitis is a chronic swelling of the lip due to granulomatous inflammation. Miescher cheilitis is the term used when the granulomatous changes are confined to the lip. Miescher cheilitis is generally regarded as a monosymptomatic form of the Melkersson-Rosenthal syndrome, although the possibility remains that these may be 2 separate diseases. Melkersson-Rosenthal syndrome is the term used when cheilitis occurs with facial palsy and plicated tongue.

Melkersson-Rosenthal syndrome is occasionally a manifestation of Crohn disease or orofacial granulomatosis.

Pathophysiology

In granulomatous cheilitis, normal lip architecture is eventually altered by the presence of lymphoedema and noncaseating granulomas in the lamina propria.

Frequency

International

The frequency is unknown; the condition is rare.

Mortality/Morbidity

Morbidity depends on whether underlying organic disease, such as Crohn disease or sarcoidosis, is present.

Race

No racial predilection is recognized.

Sex

No sexual predilection is known.

Age

Onset usually occurs in young adult life.

Please click here to view the full topic text: Cheilitis Granulomatosa (Miescher-Melkersson-Rosenthal Syndrome)

We subscribe to the
HONcode principles of the
Health On the Net Foundation

Medicine is a constantly changing science and not all therapies are clearly established. New research changes drug and treatment therapies daily. The authors, editors, and publisher of this journal have used their best efforts to provide information that is up-to-date and accurate and is generally accepted within medical standards at the time of publication. However, as medical science is constantly changing and human error is always possible, the authors, editors, and publisher or any other party involved with the publication of this article do not warrant the information in this article is accurate or complete, nor are they responsible for omissions or errors in the article or for the results of using this information. The reader should confirm the information in this article from other sources prior to use. In particular, all drug doses, indications, and contraindications should be confirmed in the package insert. FULL DISCLAIMER