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Fractures, Pelvic

Last Updated: July 7, 2005
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Synonyms and related keywords: pelvic fracture, fracture of the pelvis, acetabular fractures, lateral compression fractures, transverse fractures of the pubic rami, avulsion fracture, Young classification system, anterior-posterior compression fractures

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Author: Charles Sheppard, MD, FACEP, Medical Director, Saint John's Life Line Air Medical Service, Department of Emergency Medicine, Saint John's Regional Medical Center

Charles Sheppard, MD, FACEP, is a member of the following medical societies: Air Medical Physician Association, American Academy of Emergency Medicine, and American College of Emergency Physicians

Editor(s): Michelle Ervin, MD, Chair, Department of Emergency Medicine, Howard University Hospital; Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine; David Levy, DO, Chairman, Associate Professor of Emergency Medicine, Department of Emergency Medicine, St. Elizabeth Health Center; John Halamka, MD, Chief Information Officer, CareGroup Healthcare System, Assistant Professor of Medicine, Department of Emergency Medicine, Beth Israel Deaconess Medical Center; Assistant Professor of Medicine, Harvard Medical School; and Scott H Plantz, MD, FAAEM, Research Director, Assistant Professor, Department of Emergency Medicine, Mount Sinai School of Medicine

Disclosure


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Background: Pelvic fracture is a disruption of the bony structure of the pelvis. In elderly persons, the most common cause is a fall from a standing position. However, the most significant fractures involve significant forces such as a motor vehicle crash or fall from a significant height.

Pathophysiology: Pelvis consists of the ilium (ie, iliac wings), ischium, and pubis, which form an anatomic ring with the sacrum. Disruption of this ring requires significant energy. Because of the forces involved, pelvic fractures frequently involve injury to organs contained within the bony pelvis. In addition, as the pelvis is supplied with a rich venous plexus as well as major arteries, fractures may produce significant bleeding.

The Young classification system incorporates anatomic mechanism of injury and identifies 4 types of ring disruption. Acetabular fractures, with or without ring disruption, also may occur. Falls in elderly persons may involve fracture (usually of the pubic rami) without disruption of the ring.

Lateral compression (LC) fractures involve transverse fractures of the pubic rami, either ipsilateral or contralateral to a posterior injury.

  • Grade I - Associated sacral compression on side of impact

  • Grade II - Associated crescent (iliac wing) fracture on side of impact

  • Grade III - Associated contralateral "open book" injury

Anterior-posterior compression (APC) fractures involve symphyseal diastasis or longitudinal rami fractures.

  • Grade I - Associated widening (slight) of pubic symphysis or of the anterior sacroiliac (SI) joint, while sacrotuberous, sacrospinous, and posterior SI ligaments remain intact

  • Grade II - Associated widening of the anterior SI joint caused by disruption of the anterior SI, sacrotuberous, and sacrospinous ligaments, while posterior SI ligaments remain intact

  • Grade III (open book) - Complete SI joint disruption with lateral displacement and disrupted anterior SI, sacrotuberous, sacrospinous, and posterior SI ligaments

Vertical shear (VS) involves symphyseal diastasis or vertical displacement anteriorly and posteriorly, which is usually through the SI joint, though occasionally through the iliac wing or sacrum.

Combined mechanical (CM) fractures involve a combination of these injury patterns, with LC/VS the most common.

Acetabular fractures most commonly involve disruption of the acetabular socket when the hip is driven backward in a motor vehicle accident. Occasionally, they will occur in a pedestrian struck by a vehicle moving at a significant rate of speed.

Frequency:

  • In the US: Pelvic fractures represent 3% of all skeletal fractures, with single pubic rami and avulsion fractures the most common.

Mortality/Morbidity: Over half of all pelvic fractures occur as a result of minimal-to-moderate trauma, such as a fall from a standing position. Of these, 95% are minor. On the other hand, the more severe pelvic fractures involve significant trauma. Most of this discussion relates to the more severe pelvic fractures.

  • The complication rate is significant and is related to injury of underlying organs and bleeding. Because of the tremendous force necessary to cause most unstable pelvic fractures, concomitant severe injuries are common and are associated with high morbidity and mortality rates. In addition, pelvic fractures increase the incidence of pulmonary emboli.
  • Overall mortality rate is approximately 10% in adults and 5% in children. Pelvic hemorrhage is the direct cause of death in fewer than half of patients with pelvic fractures who die. Retroperitoneal hemorrhage and secondary infection are the main causes of death in children and adults with pelvic fractures.
  • If hypotension is present on arrival to the emergency department, the mortality rate approaches 50%. If the fracture is open, the mortality rate reaches 30%.

Sex:

  • Associated genitourinary (GU) injuries vary greatly between men and women and are discussed in other articles. For many years, it was felt that women did not suffer urethral injuries. It is now well known that, while women suffer urethral injuries at a much lower incidence than men, injuries do occur. Women suffer partial lacerations and partial disruption with complete disruption being rare.

Age:

  • Age distribution largely matches that of motor vehicle crashes, with car-car injuries more prevalent in adults, especially younger adults, and car-pedestrian injuries more likely to cause injury in children. The other group is the elderly who tend to suffer pubic rami fractures without internal injuries in standing falls.
  • Urethral injuries vary widely by age with injuries to the prostatic urethra and bladder neck limited to children. Direct lacerations to the urethra occur only in boys (small prostate) and women.
  • The incidence of urethral injuries also varies by the type of pelvic fracture. Straddle fractures associated with sacroiliac diastasis have the highest incidence (odds ratio of 24). Without diastasis, the odd ratio dropped to 3.85. Urethral injuries were essentially nonexistent for fractures not involving the ischiopubic rami.


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History:

  • Basic mechanism of significant blunt trauma should prompt consideration of a pelvic fracture.

Physical:

  • Tenderness over the pelvis that can be appreciated with pelvic springing indicates fracture. Pelvic springing involves applying alternating gentle compression and distortion over the iliac wings.
  • Palpable instability of the pelvis on bimanual compression or distraction of the iliac wings also indicates fracture. Be very gentle when pelvic tenderness is appreciated. Do not rock or apply great force until radiographs exclude skeletally unstable pelvic fractures, since an overly aggressive examination can increase hemorrhage unnecessarily. Likewise, examination should be limited to one examiner. Remember that, in the later stages of pregnancy, the pelvic ligaments become stretched and may mimic instability.
  • Instability on hip adduction and pain on hip motion suggests an acetabular fracture (in addition to possible hip fracture).
  • Signs of urethral injury in males include a high-riding or boggy prostate on rectal exam, scrotal hematoma, or blood at the urethral meatus.
  • Vaginal bleeding or palpable fracture line on careful bimanual exam suggests pelvic fracture in females.
  • Other signs of pelvic fracture include the following:
    • Hematuria
    • Rectal bleeding or Earle sign, the appreciation of a large hematoma or palpable fracture line on careful rectal exam
    • Destot sign, a hematoma above the inguinal ligament, on the proximal thigh, or over the perineum
    • Grey Turner sign, a flank ecchymosis associated with retroperitoneal bleeding
    • Roux sign, a bilateral asymmetry in the distances between the greater trochanter and the pubic spine on each side (indicating an overriding fracture of the anterior pelvic ring)
    • Neurovascular deficits of the lower extremities

Causes:

  • Adults with significant pelvic fracture
    • Motor vehicle crash (50-60%)
    • Motorcycle crash (10-20%)
    • Pedestrian versus car (10-20%)
    • Falls (8-10%)
    • Crush (3-6%)
  • Children
    • Pedestrian versus car (60-80%)
    • Motor vehicle crash (20-30%)
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Abdominal Pain in Elderly Persons
Abdominal Trauma, Blunt
Dislocations, Hip
Fractures, Hip
Pregnancy, Trauma
Shock, Hemorrhagic
Trauma, Lower Genitourinary


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  WORKUP Section 5 of 10   Click here to go to the previous section in this topic Click here to go to the top of this page Click here to go to the next section in this topic
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Lab Studies:

  • Serial hemoglobin and hematocrit measurements monitor ongoing blood loss.
  • Urinalysis may reveal gross or microscopic hematuria.
  • Pregnancy test is indicated in females of childbearing age to detect pregnancy as well as potential bleeding sources (eg, miscarriage, abruptio placentae).

Imaging Studies:

  • Radiographs
    • Anteroposterior pelvic radiograph is the basic screening test and uncovers 90% of pelvic injuries.
    • Additional views include outlet (40 degrees cephalad) and inlet (40 degrees caudad) views.
    • Judet (oblique) views show better detail of the acetabulum.
  • Findings may be divided into 1 of 4 categories according to the Kane classification system.
    • Kane type I represents fractures of only 1 pelvic bone and no interruption of the anatomic ring, such as an avulsion of the anterior superior iliac spine. In general, these fractures have no significant associated injuries and require only rest and analgesia.
    • Kane type II represents single breaks in the ring near the pubic symphysis or an SI joint (since this can occur only near a flexible area). These are skeletally stable, requiring only rest and analgesia, but may be associated with significant GU/intra-abdominal injuries.
    • Kane type III represents double breaks in the ring and therefore is skeletally unstable. These include straddle (bilateral double rami) fractures, Malgaigne (double vertical; unilateral double rami plus iliac) fractures, and open book disruption (of pubic symphysis and SI joint). Most are associated with significant hemorrhage and GU/intra-abdominal injuries.
    • Kane type IV represents acetabular fractures, which frequently are associated with GU/intra-abdominal injuries because of the force required.
  • Computed tomography
    • If a fracture is present or suspected and the patient is medically stable, order a pelvic CT scan, in addition to other necessary CT scans, to determine whether concomitant injury is present.
    • CT scan is the best imaging study for evaluation of pelvic anatomy and degree of pelvic, retroperitoneal, and intraperitoneal bleeding. CT scan also confirms hip dislocation associated with an acetabular fracture. CT scanning has largely replaced plain radiographs except for screening, and it has virtually eliminated the use of auxiliary views.
  • Ultrasonography
    • As part of the Focused Assessment with Sonography for Trauma (FAST) examination, the pelvis should be visualized for intrapelvic bleeding/fluid. In addition, the FAST examination should determine intraperitoneal bleeding to explain shock.
    • Absence of intraperitoneal fluid and lack of a hemothorax in a patient in shock would indicate the pelvis as a likely source.
  • Urethrography: Retrograde urethrography is necessary for males with a displaced or boggy prostate or blood at the urethral meatus and for females in whom a Foley catheter cannot easily pass on gentle attempts. This study should also be used in females with a vaginal tear or palpable fracture fragments adjacent to the urethra.
  • Arteriography
    • Consider this study in hemodynamically unstable patients when ultrasonography, CT scanning, or peritoneal tap excludes significant intraperitoneal bleeding and after external pelvis is stabilized.

    • This study allows for determination of the bleeding site and, potentially, embolization as a means of control.
  • Cystography: Consider this study in any patient with hematuria and an intact urethra.

Procedures:

  • Use a suprapubic catheter for patients in whom urethral injuries are suspected but a urethrogram cannot be obtained.
  • Use an external compression device, sheets, or possibly a pneumatic antishock garment (PASG) to control bleeding and temporarily stabilize pelvis.
  • External pelvic fixation may be necessary to decrease bleeding and prevent further damage.
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Prehospital Care:

  • Address acute life-threatening conditions. Be very aware that the amount of force necessary to cause a significant pelvic fracture is likely to have caused other significant injuries.
  • Consider use of PASG to mechanically stabilize the pelvis if grossly unstable.
  • Avoid excessive movement of pelvis.
  • Establish large-bore intravenous (IV) access and administer fluids as needed.
  • Closely monitor vital signs.

Emergency Department Care:

  • Investigate associated intra-abdominal and intrapelvic injuries. A FAST exam should be performed as soon as possible, as well as a chest radiography to look for other bleeding sources, especially in the unstable patient.
  • Avoid excessive movement of the pelvis. The pelvis should be rapidly stabilized with a sheet or commercial pelvic external stabilizer. This is very important prior to neuromuscular blockade because the muscles may be the only thing maintaining pelvic stability.
  • Consider orthopedic applied external fixation for skeletally unstable fractures.
  • Administer fluid replacement and analgesics as needed.
  • Do not place urinary catheter until urethral injury has been ruled out by physical exam or retrograde urethrography.
  • Obtain CT scan of pelvis as soon as practical.
  • Consider angiography as soon a possible in the unstable patient without other bleeding sources.

Consultations:

  • Consult an orthopedic surgeon when a pelvic fracture is diagnosed. Hemodynamically unstable patients (with unstable pelvic fractures) require emergent orthopedic consultation for possible external fixation.
  • Consult an interventional radiologist for embolization in the unstable patient.
  • Consult a urologist for any suspected urethral injury.

  MEDICATION Section 7 of 10   Click here to go to the previous section in this topic Click here to go to the top of this page Click here to go to the next section in this topic
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Primary treatment is for pain with narcotic analgesics. Administer antibiotics whenever disruption of bowel, vagina, or urinary tract is suspected. Since bleeding is the major life-threatening complication of pelvic fractures, avoid nonsteroidal anti-inflammatory drugs in initial treatment. They may be considered later if inflammation is a concern.

Drug Category: Analgesics -- Narcotic analgesics are the treatment of choice in the acute setting. Pain control is essential to quality patient care. It ensures patient comfort, promotes pulmonary toilet, and aids physical therapy regimens. Many analgesics have sedating properties that benefit patients who have sustained fractures. Adequate pain control helps keep the patient quiet and avoids movement of the pelvis.
Drug Name
Morphine sulfate (Duramorph, Astramorph, MS Contin) -- DOC for narcotic analgesia because of its reliable and predictable effects, safety, and ease of reversibility with naloxone. Administered IV, may be dosed in a number of ways and commonly is titrated until desired effect obtained. Titrated doses especially useful in trauma patients to avoid oversedation or hypotension. Caution in hypotensive patients as may worsen hypotension because of histamine release. Consider fentanyl in this setting.
Adult DoseStarting dose: 0.1 mg/kg IV
Maintenance dose: 5-20 mg/70 kg IV/IM/SC q4h
Relatively hypovolemic patients: Start with 2 mg IV and reassess hemodynamic effects of dose
Pediatric DoseNeonates: 0.05-0.2 mg/kg IV/IM/SC q2-4h prn
Children: 0.1-0.2 mg/kg IV/IM/SC q2-4h prn
ContraindicationsDocumented hypersensitivity; hypotension; potentially compromised airway in which establishing rapid airway control would be difficult
Interactions Phenothiazines may antagonize analgesic effects; tricyclic antidepressants, MAOIs, and other CNS depressants may potentiate adverse effects
Pregnancy C - Safety for use during pregnancy has not been established.
PrecautionsAvoid in hypotension, respiratory depression, nausea, emesis, constipation, and urinary retention; caution in atrial flutter and other supraventricular tachycardias; has vagolytic action and may increase ventricular response rate
Drug Name
Fentanyl (Sublimaze, Duragesic) -- Excellent drug for analgesia in patients with hypotension or whose cardiovascular condition is unstable. Does not release histamine. Short-acting acutely, duration becomes longer with repetitive dosing.
Adult Dose1-2 mcg/kg IV then titrate to pain relief
Pediatric Dose2-3 mcg/kg IV then titrate to pain relief
ContraindicationsDocumented hypersensitivity; hypotension; potentially compromised airway in which establishing rapid airway control would be difficult
InteractionsPhenothiazines may antagonize analgesic effects; tricyclic antidepressants may potentiate adverse effects
Pregnancy C - Safety for use during pregnancy has not been established.
PrecautionsCaution in hypotension, respiratory depression, constipation, nausea, emesis, and urinary retention; idiosyncratic reaction, known as chest wall rigidity syndrome (never reported in analgesic dosages, <200 mcg bolus), may require neuromuscular blockade to increase ventilation
Drug Name
Meperidine (Demerol) -- No more effective than morphine or fentanyl, shorter acting and more adverse effects. Useful in patients allergic to morphine and fentanyl.
Adult Dose0.25-1 mg/kg IV titrate to pain relief
Pediatric DoseAdminister as in adults
ContraindicationsDocumented hypersensitivity; concurrent MAOIs; upper airway obstruction or significant respiratory depression; during labor when delivery of premature infant is anticipated
InteractionsConcurrent cimetidine requires monitoring for increased respiratory and CNS depression; hydantoins may decrease effects; avoid with protease inhibitors
Pregnancy C - Safety for use during pregnancy has not been established.
PrecautionsCaution in patients with head injuries since may increase respiratory depression and CSF pressure (use only if absolutely necessary); caution when using postoperatively and with history of pulmonary disease (suppresses cough reflex); substantially increased dose levels, due to tolerance, may aggravate or cause seizures even if no prior history of convulsive disorders; monitor closely for meperidine-induced seizure activity if prior seizure history; toxic metabolites may accumulate in pediatric patients, those with renal failure, or in repetitive dosing
Drug Name
Acetaminophen (Tylenol, Panadol, aspirin-free Anacin) -- DOC for treatment of pain in patients with documented hypersensitivity to aspirin or NSAIDs or those at high risk of bleeding, with upper GI disease, or taking oral anticoagulants. DOC for pain relief in noninflammatory conditions.
Adult Dose325-650 mg PO q4-6h or 1000 mg tid/qid; not to exceed 4 g/d
Pediatric Dose<12 years: 10-15 mg/kg/dose PO q4-6h prn; not to exceed 2.6 g/d
>12 years: 325-650 mg q4h; not to exceed 5 doses/d
ContraindicationsDocumented hypersensitivity; known G-6-P deficiency
InteractionsRifampin can reduce analgesic effects; barbiturates, carbamazepine, hydantoins, and isoniazid may increase hepatotoxicity
Pregnancy B - Usually safe but benefits must outweigh the risks.
PrecautionsSevere or recurrent pain or high or continued fever may indicate a serious illness; APAP is contained in many OTC products and combined use with these products may result in cumulative APAP doses exceeding recommended maximum dose
Drug Name
Acetaminophen and codeine (Tylenol #3) -- Drug combination indicated for treatment of mild to moderately severe pain. Relatively poor choice in most situations as better analgesics with fewer adverse effects exist.
Adult Dose30-60 mg/dose based on codeine content PO q4-6h or 1-2 tabs q4h; not to exceed 12 tabs/d
Pediatric Dose0.5-1 mg/kg/dose based on codeine content PO q4-6h; 10-15 mg/kg/dose based on acetaminophen content; not to exceed 2.6 g/d of acetaminophen
ContraindicationsDocumented hypersensitivity
InteractionsCNS depressants or tricyclic antidepressants increase toxicity
Pregnancy C - Safety for use during pregnancy has not been established.
PrecautionsCaution in patients dependent on opiates since this substitution may result in acute opiate-withdrawal symptoms; caution in severe renal or hepatic dysfunction
Drug Name
Hydrocodone bitartrate and acetaminophen (Vicodin ES) -- Drug combination indicated for relief of moderately severe to severe pain.
Adult Dose1-2 tab/cap PO q4-6h prn based on hydrocodone content 5-10 mg dosage
Pediatric Dose<12 years: 10-15 mg/kg/dose acetaminophen PO q4-6h prn; not to exceed 2.6 g/d of acetaminophen
>12 years: 750 mg acetaminophen PO q4h; single dose not to exceed 10 mg of hydrocodone bitartrate; not to exceed 5 doses/d
ContraindicationsDocumented hypersensitivity; high-altitude cerebral edema; elevated intracranial pressure
InteractionsPhenothiazines may decrease analgesic effects; CNS depressants or tricyclic antidepressants increase toxicity
Pregnancy C - Safety for use during pregnancy has not been established.
PrecautionsTablets contain metabisulfite which may cause hypersensitivity; caution in patients dependent on opiates since this substitution may result in acute opiate-withdrawal symptoms; caution in severe renal or hepatic dysfunction; be careful when adding to other drugs that contain acetaminophen
Drug Name
Oxycodone and acetaminophen (Percocet, Tylox, Roxicet, Roxilox) -- Drug combination indicated for relief of moderately severe to severe pain. DOC for aspirin-hypersensitive patients.
Adult Dose1-2 tab/cap PO q4-6h prn
Pediatric Dose0.05-0.15 mg/kg/dose oxycodone PO q4-6h prn; not to exceed 5 mg/dose of oxycodone
ContraindicationsDocumented hypersensitivity
InteractionsPhenothiazines may decrease analgesic effects; CNS depressants or tricyclic antidepressants increase toxicity
Pregnancy C - Safety for use during pregnancy has not been established.
PrecautionsDuration of action may increase in the elderly; be aware of total daily dose of acetaminophen patient is receiving; do not exceed 4000 mg/24h of acetaminophen; higher doses may cause liver toxicity
Drug Name
Oxycodone and aspirin (Percodan, Roxiprin) -- Drug combination indicated for relief of moderately severe to severe pain. Avoid in early treatment because of platelet inhibition from aspirin and increased risk of bleeding. See discussion under NSAIDs above.
Adult Dose1-2 tabs/caps PO q4-6h prn
Pediatric Dose0.05-0.15 mg/kg/dose oxycodone PO q4-6h prn; not to exceed 5 mg/dose of oxycodone
ContraindicationsDocumented hypersensitivity; liver damage; hypoprothrombinemia; vitamin K deficiency; bleeding disorders; asthma
Because of association with Reye syndrome, do not use in children (<16 y) who have flu
InteractionsPhenothiazines may decrease analgesic effects; CNS depressants or tricyclic antidepressants increase toxicity; may potentiate anticoagulant effects of warfarin
Pregnancy D - Unsafe in pregnancy
PrecautionsDuration of action may increase in the elderly; caution in renal or liver impairment, peptic ulcer disease, and erosive gastritis
Drug Category: Antibiotics -- Empiric antimicrobial therapy must be comprehensive and should cover all likely pathogens in the clinical setting.
Drug Name
Gentamicin (Gentacidin, Garamycin) -- Aminoglycoside antibiotic used for gram-negative bacterial coverage. Commonly used in combination with both an agent against gram-positive organisms and one that covers anaerobes. Used in conjunction with ampicillin or vancomycin and/or metronidazole for prophylaxis in patients with suspected disruption of bowel, vagina, or urinary tract. Dosing regimens are numerous and are adjusted based on CrCl and changes in volume of distribution. Gentamicin may be given IV/IM.
Adult DoseOlder patients: 4 mg/kg IV
Younger patients: 5 mg/kg IV
Pediatric Dose2 mg/kg IV
ContraindicationsDuration of action may increase in the elderly; caution in renal or liver impairment, peptic ulcer disease, and erosive gastritis
InteractionsOther aminoglycosides, cephalosporins, penicillins, and amphotericin B may increase nephrotoxicity; aminoglycosides enhance effects of neuromuscular blocking agents, thus prolonged respiratory depression may occur; coadministration with loop diuretics may increase auditory toxicity of aminoglycosides—possible irreversible hearing loss of varying degrees may occur (monitor regularly)
Pregnancy C - Safety for use during pregnancy has not been established.
PrecautionsNarrow therapeutic index (not intended for long-term therapy); caution in renal failure (not on dialysis), myasthenia gravis, hypocalcemia, and conditions that depress neuromuscular transmission; adjust dose in renal impairment
Drug Name
Ampicillin (Omnipen, Marcillin) -- Interferes with bacterial cell wall synthesis during active replication, causing bactericidal activity against susceptible organisms.
Adult Dose2 g IV/IM
Pediatric Dose50 mg/kg IV/IM
ContraindicationsDocumented hypersensitivity
InteractionsProbenecid and disulfiram elevate ampicillin levels; allopurinol decreases effects and has additive effects on ampicillin rash; may decrease effects of oral contraceptives
Pregnancy B - Usually safe but benefits must outweigh the risks.
PrecautionsAdjust dose in renal failure; evaluate rash and differentiate from hypersensitivity reaction
Drug Name
Vancomycin (Vancocin) -- Potent antibiotic directed against gram-positive organisms and active against enterococcal species. Also useful in treatment of septicemia and skin-structure infections. Used in conjunction with gentamicin for prophylaxis in patients with GI or GU trauma.
Adult Dose1 g IV infused over 1 h
Pediatric Dose1 g IV infused over 1 h
ContraindicationsDocumented hypersensitivity
InteractionsErythema, histaminelike flushing, and anaphylactic reactions may occur when administered with anesthetic agents; taken concurrently with aminoglycosides, risk of nephrotoxicity may increase above that with aminoglycoside monotherapy; effects in neuromuscular blockade may be enhanced when coadministered with nondepolarizing muscle relaxants
Pregnancy C - Safety for use during pregnancy has not been established.
PrecautionsCaution in renal failure, neutropenia; red man syndrome caused by too rapid IV infusion (dose given over a few minutes) but rarely happens when dose given over 2 h or by PO or IP route; red man syndrome not an allergic reaction
Drug Name
Metronidazole (Flagyl) -- Provides coverage against anaerobic bacteria (important if bowel contents contaminate peritoneal cavity).
Adult DoseLoading dose: 15 mg/kg IV (approximately 1 g); followed by 7.5 mg/kg IV q6h
Pediatric DoseNot recommended
ContraindicationsDocumented hypersensitivity
InteractionsMay increase toxicity of anticoagulants, lithium, and phenytoin; cimetidine may increase toxicity; disulfiram reaction may occur with orally ingested ethanol
Pregnancy B - Usually safe but benefits must outweigh the risks.
PrecautionsAdjust dose in hepatic disease; monitor for seizures and development of peripheral neuropathy
  FOLLOW-UP Section 8 of 10   Click here to go to the previous section in this topic Click here to go to the top of this page Click here to go to the next section in this topic
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Further Inpatient Care:

Further Outpatient Care:

In/Out Patient Meds:

Transfer:

Deterrence/Prevention:

Complications:

Prognosis:

Patient Education:

  MISCELLANEOUS Section 9 of 10   Click here to go to the previous section in this topic Click here to go to the top of this page Click here to go to the next section in this topic
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Medical/Legal Pitfalls:

  • Failure to diagnose an underlying injury, especially urethral disruption

  • Failure to consider a urethral injury in a female
  • Failure to clinically (or radiographically) exclude urethral injury prior to attempting to insert a urinary catheter in a male

  • Failure to obtain urethroscopy in women with suspected urethral injuries
  • Failure to cease attempted Foley catheterization in a female after encountering resistance
  • Failure to document the presence or absence of vaginal bleeding in a female with a pelvic fracture
  • Failure to diagnose a hip dislocation associated with an acetabular fracture
  • Failure to appreciate ongoing blood loss
  • Failure to diagnose concomitant intra-abdominal or retroperitoneal injuries
  • Failure to obtain prompt orthopedic consultation for an unstable pelvic fracture
  • Failure to promptly apply external stabilization to an unstable pelvic fracture

Special Concerns:

  • Pregnant patients
    • Patients in later stages of pregnancy are at increased risk for complications.
    • Risk of placental abruption and uterine rupture is great.
  BIBLIOGRAPHY Section 10 of 10   Click here to go to the previous section in this topic Click here to go to the top of this page
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  • Biffl WL, Smith WR, Moore EE, et al: Evolution of a multidisciplinary clinical pathway for the management of unstable patients with pelvic fractures. Ann Surg 2001 Jun; 233(6): 843-50[Medline].
  • Burgess AR, Eastridge BJ, Young JW: Pelvic ring disruptions: effective classification system and treatment protocols. J Trauma 1990 Jul; 30(7): 848-56[Medline].
  • Cerva DS Jr, Mirvis SE, Shanmuganathan K: Detection of bleeding in patients with major pelvic fractures: value of contrast-enhanced CT. AJR Am J Roentgenol 1996 Jan; 166(1): 131-5[Medline].
  • Eichelberger MR: Pelvic and Retroperitoneal Trauma. In: Pediatric Trauma. 1993; 520-529.
  • Grimm MR, Vrahas MS, Thomas KA: Pressure-volume characteristics of the intact and disrupted pelvic retroperitoneum. J Trauma 1998 Mar; 44(3): 454-9[Medline].
  • Hart RG, Rittenberry TJ, Uehara DT: Handbook of Orthopaedic Emergencies. Lippincott-Raven; 1999: 277-297.
  • Ismail N, Bellemare JF, Mollitt DL: Death from pelvic fracture: children are different. J Pediatr Surg 1996 Jan; 31(1): 82-5[Medline].
  • Knudson MM, Ikossi DG, Khaw L, et al: Thromboembolism after trauma: an analysis of 1602 episodes from the American College of Surgeons National Trauma Data Bank. Ann Surg 2004 Sep; 240(3): 490-6; discussion 496-8[Medline].
  • Koraitim MM: Pelvic fracture urethral injuries: the unresolved controversy. J Urol 1999 May; 161(5): 1433-41[Medline].
  • Mubarak SJ, Lavernia C, Silva PD: Ice-cream truck-related injuries to children. J Pediatr Orthop 1998 Jan-Feb; 18(1): 46-8[Medline].
  • Reichard SA, Helikson MA, Shorter N: Pelvic fractures in children--review of 120 patients with a new look at general management. J Pediatr Surg 1980 Dec; 15(6): 727-34[Medline].
  • Riemer BL, Butterfield SL, Diamond DL: Acute mortality associated with injuries to the pelvic ring: the role of early patient mobilization and external fixation. J Trauma 1993 Nov; 35(5): 671-5; discussion 676-7[Medline].
  • Scaletta TA, Schaider JJ: Emergent Management of Trauma. McGraw-Hill; 1996: 187-191.
  • Smith JM: Pelvic fractures. West J Med 1998 Feb; 168(2): 124-5[Medline].
  • Wiss DA: What's new in orthopaedic trauma. J Bone Joint Surg Am 2001 Nov; 83-A(11): 1762-72[Medline].

Fractures, Pelvic excerpt